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Estimated Brain Tissue Response Following Impacts Associated With and Without Diagnosed Concussion.
Beckwith, Jonathan G; Zhao, Wei; Ji, Songbai; Ajamil, Amaris G; Bolander, Richard P; Chu, Jeffrey J; McAllister, Thomas W; Crisco, Joseph J; Duma, Stefan M; Rowson, Steven; Broglio, Steven P; Guskiewicz, Kevin M; Mihalik, Jason P; Anderson, Scott; Schnebel, Brock; Gunnar Brolinson, P; Collins, Michael W; Greenwald, Richard M.
Afiliación
  • Beckwith JG; Simbex, 10 Water Street Suite 410, Lebanon, NH, 03748, USA. jbeckwith@simbex.com.
  • Zhao W; Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA, USA.
  • Ji S; Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA, USA.
  • Ajamil AG; Thayer School of Engineering, Dartmouth College, Hanover, NH, USA.
  • Bolander RP; Simbex, 10 Water Street Suite 410, Lebanon, NH, 03748, USA.
  • Chu JJ; Simbex, 10 Water Street Suite 410, Lebanon, NH, 03748, USA.
  • McAllister TW; Simbex, 10 Water Street Suite 410, Lebanon, NH, 03748, USA.
  • Crisco JJ; Department of Psychiatry, Indiana School of Medicine, Indianapolis, IA, USA.
  • Duma SM; Department of Orthopaedics, Alpert Medical School of Brown University and Rhode Island Hospital, Providence, RI, USA.
  • Rowson S; Department of Biomedical Engineering and Mechanics, Virginia Tech, Blacksburg, VA, USA.
  • Broglio SP; Department of Biomedical Engineering and Mechanics, Virginia Tech, Blacksburg, VA, USA.
  • Guskiewicz KM; NeuroTrauma Research Laboratory, University of Michigan, Ann Arbor, MI, USA.
  • Mihalik JP; Matthew Gfeller Sport-Related Traumatic Brain Injury Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Anderson S; Matthew Gfeller Sport-Related Traumatic Brain Injury Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Schnebel B; Department of Intercollegiate Athletics, University of Oklahoma, Norman, OK, USA.
  • Gunnar Brolinson P; Departments of Orthopedics and Athletics, University of Oklahoma, Norman, OK, USA.
  • Collins MW; Edward Via College of Osteopathic Medicine, Blacksburg, VA, USA.
  • Greenwald RM; Departments of Orthopaedic Surgery and Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Ann Biomed Eng ; 46(6): 819-830, 2018 Jun.
Article en En | MEDLINE | ID: mdl-29470745
Kinematic measurements of head impacts are sensitive to sports concussion, but not highly specific. One potential reason is these measures reflect input conditions only and may have varying degrees of correlation to regional brain tissue deformation. In this study, previously reported head impact data recorded in the field from high school and collegiate football players were analyzed using two finite element head models (FEHM). Forty-five impacts associated with immediately diagnosed concussion were simulated along with 532 control impacts without identified concussion obtained from the same players. For each simulation, intracranial response measures (max principal strain, strain rate, von Mises stress, and pressure) were obtained for the whole brain and within four regions of interest (ROI; cerebrum, cerebellum, brain stem, corpus callosum). All response measures were sensitive to diagnosed concussion; however, large inter-athlete variability was observed and sensitivity strength depended on measure, ROI, and FEHM. Interestingly, peak linear acceleration was more sensitive to diagnosed concussion than all intracranial response measures except pressure. These findings suggest FEHM may provide unique and potentially important information on brain injury mechanisms, but estimations of concussion risk based on individual intracranial response measures evaluated in this study did not improve upon those derived from input kinematics alone.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Mecánico / Encéfalo / Conmoción Encefálica / Fútbol Americano Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Humans / Male Idioma: En Revista: Ann Biomed Eng Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Mecánico / Encéfalo / Conmoción Encefálica / Fútbol Americano Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Humans / Male Idioma: En Revista: Ann Biomed Eng Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos