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SDF 1-alpha Attenuates Myocardial Injury Without Altering the Direct Contribution of Circulating Cells.
Goldstone, Andrew B; Burnett, Cassandra E; Cohen, Jeffery E; Paulsen, Michael J; Eskandari, Anahita; Edwards, Bryan E; Ingason, Arnar B; Steele, Amanda N; Patel, Jay B; MacArthur, John W; Shizuru, Judith A; Woo, Y Joseph.
Afiliación
  • Goldstone AB; Department of Cardiothoracic Surgery, School of Medicine, Stanford University, Stanford, CA, USA.
  • Burnett CE; Division of Blood and Marrow Transplantation, Department of Medicine, School of Medicine, Stanford University, Stanford, CA, USA.
  • Cohen JE; Department of Cardiothoracic Surgery, School of Medicine, Stanford University, Stanford, CA, USA.
  • Paulsen MJ; Department of Cardiothoracic Surgery, School of Medicine, Stanford University, Stanford, CA, USA.
  • Eskandari A; Department of Cardiothoracic Surgery, School of Medicine, Stanford University, Stanford, CA, USA.
  • Edwards BE; Department of Cardiothoracic Surgery, School of Medicine, Stanford University, Stanford, CA, USA.
  • Ingason AB; Department of Cardiothoracic Surgery, School of Medicine, Stanford University, Stanford, CA, USA.
  • Steele AN; Department of Cardiothoracic Surgery, School of Medicine, Stanford University, Stanford, CA, USA.
  • Patel JB; Department of Cardiothoracic Surgery, School of Medicine, Stanford University, Stanford, CA, USA.
  • MacArthur JW; Department of Cardiothoracic Surgery, School of Medicine, Stanford University, Stanford, CA, USA.
  • Shizuru JA; Division of Blood and Marrow Transplantation, Department of Medicine, School of Medicine, Stanford University, Stanford, CA, USA.
  • Woo YJ; Department of Cardiothoracic Surgery, School of Medicine, Stanford University, Stanford, CA, USA. joswoo@stanford.edu.
J Cardiovasc Transl Res ; 11(4): 274-284, 2018 08.
Article en En | MEDLINE | ID: mdl-29468554
Stromal cell-derived factor 1-alpha (SDF) is a potent bone marrow chemokine capable of recruiting circulating progenitor populations to injured tissue. SDF has known angiogenic capabilities, but bone marrow-derived cellular contributions to tissue regeneration remain controversial. Bone marrow from DsRed-transgenic donors was transplanted into recipients to lineage-trace circulating cells after myocardial infarction (MI). SDF was delivered post-MI, and hearts were evaluated for recruitment and plasticity of bone marrow-derived populations. SDF treatment improved ventricular function, border zone vessel density, and CD31+ cell frequency post-MI. Bone marrow-derived endothelial cells were observed; these cells arose through both cell fusion and transdifferentiation. Circulating cells also adopted cardiomyocyte fates, but such events were exceedingly rare and almost exclusively resulted from cell fusion. SDF did not significantly alter the proportion of circulating cells that adopted non-hematopoietic fates. Mechanistic insight into the governance of circulating cells is essential to realizing the full potential of cytokine therapies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Miocitos Cardíacos / Quimiocina CXCL12 / Infarto del Miocardio Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Cardiovasc Transl Res Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Miocitos Cardíacos / Quimiocina CXCL12 / Infarto del Miocardio Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Cardiovasc Transl Res Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos