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Candidate SNP of CACNA2D1 Gene Associated with Clinical Mastitis and Production Traits in Sahiwal (Bos taurus indicus) and Karan Fries (Bos taurus taurus × Bos taurus indicus).
Magotra, Ankit; Gupta, I D; Verma, Archana; Alex, Rani; Mr, Vineeth; Ahmad, Tavsief.
Afiliación
  • Magotra A; a Department of Animal Genetics and Breeding , LUVAS , Hisar , Haryana , India.
  • Gupta ID; b Dairy Cattle Breeding Division , ICAR- National Dairy Research Institute , Karnal , Haryana , India.
  • Verma A; b Dairy Cattle Breeding Division , ICAR- National Dairy Research Institute , Karnal , Haryana , India.
  • Alex R; c Department of Animal Genetics and Breeding , Central Institute of Research on Cattle , Meerut , Uttar Pradesh , India.
  • Mr V; b Dairy Cattle Breeding Division , ICAR- National Dairy Research Institute , Karnal , Haryana , India.
  • Ahmad T; d Department of Animal Genetics and Breeding , FVSC & AH, SKUAST-K , Jammu and Kashmir , India.
Anim Biotechnol ; 30(1): 75-81, 2019 Jan.
Article en En | MEDLINE | ID: mdl-29463160
The present study was conducted to identify polymorphisms in CACNA2D1 gene and their association with clinical mastitis and production traits. Exon 18 and its flanking regions were screened for the presence of SNPs. Statistical analysis was performed to identify association of period of birth, breed, and genotype with mastitis incidence on randomly selected 103 Sahiwal and 102 Karan Fries cattle. PCR-RFLP analysis revealed that g.38819398G > A mutation in exon 18 (269 bp amplicon) of CACNA2D1 gene resolved into AA, AG, and GG genotypes in Sahiwal and Karan Fries cattle. Wald chi-square analysis revealed that the period of birth, breed, and genotype were significantly associated with mastitis incidence. GG genotyped cattle were found to be less susceptible to mastitis. Least square analysis revealed that GG and AG genotype animals of G38819398A SNP of CACNA2D1 gene in Sahiwal as well as in Karan Fries cattle were associated with higher average milk yields during 1st, 2nd, and 3rd lactations (P < 0.01). These observations and their differential association with the incidence of mastitis and production traits can be utilized as an aid to selection for simultaneous improvement of both antagonistic traits; however, validation of results on large number of animals is warranted.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo de Nucleótido Simple / Mastitis Bovina Tipo de estudio: Risk_factors_studies Límite: Animals País/Región como asunto: Asia Idioma: En Revista: Anim Biotechnol Asunto de la revista: BIOTECNOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo de Nucleótido Simple / Mastitis Bovina Tipo de estudio: Risk_factors_studies Límite: Animals País/Región como asunto: Asia Idioma: En Revista: Anim Biotechnol Asunto de la revista: BIOTECNOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido