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Antifungal activity of Annona coriacea Mart. ethanol extracts against the aetiological agents of cryptococcosis.
Almeida-Apolonio, Adriana Araújo de; Dantas, Fabiana Gomes da Silva; Rodrigues, Allan Belarmino; Cardoso, Claudia Andréa Lima; Negri, Melyssa; Oliveira, Kelly Mari Pires de; Chang, Marilene Rodrigues.
Afiliación
  • Almeida-Apolonio AA; a Faculdade de Medicina , Universidade Federal de Mato Grosso do Sul , Campo Grande , Brazil.
  • Dantas FGDS; b Faculdade de Ciências da Saúde , Universidade Federal da Grande Dourados , Dourados , Brazil.
  • Rodrigues AB; c Faculdade de Ciências Exatas e Tecnologia , Universidade Federal da Grande Dourados , Dourados , Brazil.
  • Cardoso CAL; d Departamento de Química , Universidade Estadual de Mato Grosso do Sul , Dourados , Brazil .
  • Negri M; e Departamento de Análise Clínicas , Universidade Estadual de Maringá , Maringá , Brazil.
  • Oliveira KMP; f Faculdade de Ciências Biológicas e Ambientais , Universidade Federal da Grande Dourados , Dourados , Brazil.
  • Chang MR; a Faculdade de Medicina , Universidade Federal de Mato Grosso do Sul , Campo Grande , Brazil.
Nat Prod Res ; 33(16): 2363-2367, 2019 Aug.
Article en En | MEDLINE | ID: mdl-29463129
Cryptococcosis is an opportunistic disease with a worldwide distribution. This disease is caused by fungi of the genus Cryptococcus, and its treatment is limited to several antifungals. In this study, the antifungal, cytotoxic and mutagenic properties of ethanol extracts from the bark and leaves of Annona coriacea were evaluated against the standard Cryptococcus species and clinical yeast specimens. Both extracts of A. coriacea showed inhibitory activity of 1.5 mg/mL for all of the yeasts tested. The number of viable cells at the lowest tested concentration was 0.187 mg/mL. The extracts that were tested showed inhibitory activity and reduced the fungal growth of the Cryptococcus gattii species and Cryptococcus neoformans species complexes, suggesting that this plant may be an effective alternative treatment for cryptococcosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pruebas de Sensibilidad Microbiana / Criptococosis / Cryptococcus neoformans / Annona / Antifúngicos Tipo de estudio: Etiology_studies Idioma: En Revista: Nat Prod Res Año: 2019 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pruebas de Sensibilidad Microbiana / Criptococosis / Cryptococcus neoformans / Annona / Antifúngicos Tipo de estudio: Etiology_studies Idioma: En Revista: Nat Prod Res Año: 2019 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido