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Acute toxicity of intraoperative radiotherapy and external beam-accelerated partial breast irradiation in elderly breast cancer patients.
Jacobs, D H M; Speijer, G; Petoukhova, A L; Roeloffzen, E M A; Straver, M; Marinelli, A; Fisscher, U; Zwanenburg, A G; Merkus, J; Marijnen, C A M; Mast, M E; Koper, P C M.
Afiliación
  • Jacobs DHM; Department of Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands.
  • Speijer G; Department of Radiation Oncology, Haaglanden Medical Center, The Hague, The Netherlands.
  • Petoukhova AL; Department of Radiation Oncology, Haga Hospital, The Hague, The Netherlands.
  • Roeloffzen EMA; Department of Radiation Oncology, Haaglanden Medical Center, The Hague, The Netherlands.
  • Straver M; Department of Radiation Oncology, Isala, Zwolle, The Netherlands.
  • Marinelli A; Department of Surgery, Haaglanden Medical Center, The Hague, The Netherlands.
  • Fisscher U; Department of Surgery, Haaglanden Medical Center, The Hague, The Netherlands.
  • Zwanenburg AG; Department of Radiation Oncology, Haaglanden Medical Center, The Hague, The Netherlands.
  • Merkus J; Department of Radiation Oncology, Isala, Zwolle, The Netherlands.
  • Marijnen CAM; Department of Surgery, Haga Hospital, The Hague, The Netherlands.
  • Mast ME; Department of Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands.
  • Koper PCM; Department of Radiation Oncology, Haaglanden Medical Center, The Hague, The Netherlands.
Breast Cancer Res Treat ; 169(3): 549-559, 2018 Jun.
Article en En | MEDLINE | ID: mdl-29460031
BACKGROUND AND PURPOSE: We investigated the acute toxicity of accelerated partial breast irradiation using external beam (EB-APBI) or intraoperative radiotherapy (IORT) techniques in elderly breast cancer patients. MATERIALS AND METHODS: Women ≥ 60 years with unifocal breast tumors of ≤ 30 mm were eligible for this prospective multi-center cohort study. IORT was applied with electrons following lumpectomy (23.3 Gy). EB-APBI was delivered using 3D-CRT or IMRT in 10 daily fractions of 3.85 Gy within 6 weeks after surgery. Acute toxicity was scored using the CTCAE v3.0 at 3 months after treatment. Patient-reported symptoms were analyzed using visual analogue scales (VAS) for pain and fatigue (scale 0-10), and single items from the EORTC QLQ-C30 and Breast Cancer questionnaires. RESULTS: In total, 267 (IORT) and 206 (EB-APBI) patients were available for toxicity analysis. More patients experienced ≥ grade 2 CTCAE acute toxicity in the IORT group (10.4% IORT and 4.9% EB-APBI; p = 0.03); grade 3 toxicity was low (3.3% IORT and 1.5% EB-APBI; ns); and no grade 4 toxicity occurred. EB-APBI patients experienced less fatigue direct postoperatively (EORTC p < 0.00, VAS p < 0.00). After 3 months only pain, according to the VAS scale, was significantly worse in the EB-APBI group (p < 0.00). CONCLUSION: Acute toxicity after IORT and EB-APBI treatment is acceptable.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Braquiterapia / Neoplasias de la Mama / Cuidados Intraoperatorios Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies Aspecto: Patient_preference Límite: Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Breast Cancer Res Treat Año: 2018 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Braquiterapia / Neoplasias de la Mama / Cuidados Intraoperatorios Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies Aspecto: Patient_preference Límite: Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Breast Cancer Res Treat Año: 2018 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Países Bajos