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Staphylococcal Protein A Is a Key Factor in Neutrophil Extracellular Traps Formation.
Hoppenbrouwers, Tamara; Sultan, Andi R; Abraham, Tsion E; Lemmens-den Toom, Nicole A; Hansenová Manásková, Silvie; van Cappellen, Wiggert A; Houtsmuller, Adriaan B; van Wamel, Willem J B; de Maat, Moniek P M; van Neck, Johan W.
Afiliación
  • Hoppenbrouwers T; Department of Plastic and Reconstructive Surgery, Erasmus MC, Rotterdam, Netherlands.
  • Sultan AR; Department of Hematology, Erasmus MC, Rotterdam, Netherlands.
  • Abraham TE; Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, Netherlands.
  • Lemmens-den Toom NA; Erasmus Optical Imaging Center, Department of Pathology, Erasmus MC, Rotterdam, Netherlands.
  • Hansenová Manásková S; Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, Netherlands.
  • van Cappellen WA; Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, Netherlands.
  • Houtsmuller AB; Erasmus Optical Imaging Center, Department of Pathology, Erasmus MC, Rotterdam, Netherlands.
  • van Wamel WJB; Erasmus Optical Imaging Center, Department of Pathology, Erasmus MC, Rotterdam, Netherlands.
  • de Maat MPM; Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, Netherlands.
  • van Neck JW; Department of Hematology, Erasmus MC, Rotterdam, Netherlands.
Front Immunol ; 9: 165, 2018.
Article en En | MEDLINE | ID: mdl-29459871
Staphylococcus aureus are strong inducers of neutrophil extracellular traps (NETs), a defense mechanism of neutrophils against pathogens. Our aim was to explore the role of Protein A in S. aureus-induced NETosis. We determined the Protein A production of four different S. aureus strains and found a direct relationship between the degree of NETosis induction and Protein A production: strains producing higher concentrations of Protein A evoke significantly more NETs. A S. aureus strain in which Protein A as well as a second binding protein for immunoglobulins (Sbi) have been knocked-out (ΔSpA ΔSbi) induced significantly less NETosis than the wild-type strain. NETosis induction by this knockout strain can be rescued by the addition of purified Protein A. Dead S. aureus did not induce NETosis. In conclusion, Protein A is a determinant for NETosis induction by S. aureus.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína Estafilocócica A / Staphylococcus aureus / Activación Neutrófila / Trampas Extracelulares Límite: Adult / Humans / Middle aged Idioma: En Revista: Front Immunol Año: 2018 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína Estafilocócica A / Staphylococcus aureus / Activación Neutrófila / Trampas Extracelulares Límite: Adult / Humans / Middle aged Idioma: En Revista: Front Immunol Año: 2018 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Suiza