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Metabolic Predictors of Incident Coronary Heart Disease in Women.
Paynter, Nina P; Balasubramanian, Raji; Giulianini, Franco; Wang, Dong D; Tinker, Lesley F; Gopal, Shuba; Deik, Amy A; Bullock, Kevin; Pierce, Kerry A; Scott, Justin; Martínez-González, Miguel A; Estruch, Ramon; Manson, JoAnn E; Cook, Nancy R; Albert, Christine M; Clish, Clary B; Rexrode, Kathryn M.
Afiliación
  • Paynter NP; Division of Preventive Medicine (N.P.P., F.G., J.E.M., N.R.C., C.M.A., K.M.R.) npaynter@partners.org.
  • Balasubramanian R; Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst (R.B.).
  • Giulianini F; Division of Preventive Medicine (N.P.P., F.G., J.E.M., N.R.C., C.M.A., K.M.R.).
  • Wang DD; Department of Epidemiology (D.D.W., J.E.M., N.R.C.).
  • Tinker LF; Department of Nutrition (D.D.W., M.A.M.-G.), Harvard T.H. Chan School of Public Health, Boston, MA.
  • Gopal S; Fred Hutchinson Cancer Research Center, Seattle, WA (L.F.T.).
  • Deik AA; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA (S.G., A.A.D., K.B., K.A.P., J.S., C.B.C.).
  • Bullock K; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA (S.G., A.A.D., K.B., K.A.P., J.S., C.B.C.).
  • Pierce KA; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA (S.G., A.A.D., K.B., K.A.P., J.S., C.B.C.).
  • Scott J; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA (S.G., A.A.D., K.B., K.A.P., J.S., C.B.C.).
  • Martínez-González MA; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA (S.G., A.A.D., K.B., K.A.P., J.S., C.B.C.).
  • Estruch R; Department of Nutrition (D.D.W., M.A.M.-G.), Harvard T.H. Chan School of Public Health, Boston, MA.
  • Manson JE; Department of Preventive Medicine and Public Health, University of Navarra Medical School, Pamplona, Spain (M.A.M.-G.).
  • Cook NR; Department of Internal Medicine, Institut d'Investigacions Biomèdiques August Pi Sunyer, Hospital Clínic, University of Barcelona, Spain (R.E.).
  • Albert CM; Division of Preventive Medicine (N.P.P., F.G., J.E.M., N.R.C., C.M.A., K.M.R.).
  • Clish CB; Department of Epidemiology (D.D.W., J.E.M., N.R.C.).
  • Rexrode KM; Division of Preventive Medicine (N.P.P., F.G., J.E.M., N.R.C., C.M.A., K.M.R.).
Circulation ; 137(8): 841-853, 2018 02 20.
Article en En | MEDLINE | ID: mdl-29459470
BACKGROUND: Although metabolomic profiling offers promise for the prediction of coronary heart disease (CHD), and metabolic risk factors are more strongly associated with CHD in women than men, limited data are available for women. METHODS: We applied a liquid chromatography-tandem mass spectrometry metabolomics platform to measure 371 metabolites in a discovery set of postmenopausal women (472 incident CHD cases, 472 controls) with validation in an independent set of postmenopausal women (312 incident CHD cases, 315 controls). RESULTS: Eight metabolites, primarily oxidized lipids, were significantly dysregulated in cases after the adjustment for matching and CHD risk factors in both the discovery and validation data sets. One oxidized phospholipid, C34:2 hydroxy-phosphatidylcholine, remained associated with CHD after further adjustment for other validated metabolites. Subjects with C34:2 hydroxy-phosphatidylcholine levels in the highest quartile had a 4.7-fold increase in CHD odds in comparison with the lowest quartile; C34:2 hydroxy-phosphatidylcholine also significantly improved the area under the curve (P<0.01) for CHD. The C34:2 hydroxy-phosphatidylcholine findings were replicated in a third replication data set of 980 men and women (230 cardiovascular events) with a stronger association observed in women. CONCLUSIONS: These data replicate known metabolite predictors, identify novel markers, and support the relationship between lipid oxidation and subsequent CHD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfatidilcolinas / Enfermedad Coronaria / Metabolómica Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Middle aged Idioma: En Revista: Circulation Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfatidilcolinas / Enfermedad Coronaria / Metabolómica Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Middle aged Idioma: En Revista: Circulation Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos