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Near-infrared rechargeable "optical battery" implant for irradiation-free photodynamic therapy.
Hu, Lidan; Wang, Peiyuan; Zhao, Mengyao; Liu, Lu; Zhou, Lei; Li, Benhao; Albaqami, Fahad H; El-Toni, Ahmed Mohamed; Li, Xiaomin; Xie, Yang; Sun, Xiaofei; Zhang, Fan.
Afiliación
  • Hu L; Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, i-Chem, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, PR China.
  • Wang P; Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, i-Chem, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, PR China.
  • Zhao M; Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, i-Chem, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, PR China.
  • Liu L; Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, i-Chem, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, PR China.
  • Zhou L; Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, i-Chem, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, PR China.
  • Li B; Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, i-Chem, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, PR China.
  • Albaqami FH; Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
  • El-Toni AM; King Abdullah Institute for Nanotechnology, King Saud University, Riyadh, 11451, Saudi Arabia.
  • Li X; Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, i-Chem, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, PR China. Electronic address: lixm@fudan.edu.cn.
  • Xie Y; Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, 200433, PR China.
  • Sun X; Department of Spine Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, PR China.
  • Zhang F; Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, i-Chem, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, PR China. Electronic address: zhang_fan@fudan.edu.cn.
Biomaterials ; 163: 154-162, 2018 05.
Article en En | MEDLINE | ID: mdl-29459324
As a minimal or noninvasive therapeutic method for tumors, photodynamic therapy (PDT) induced by the external laser irradiations has attracted great attentions. However, the UV-visible responsive property with low tissue penetration and photothermal effect from the prolonged irradiation impedes their further applications. Herein, a near-infrared (NIR) rechargeable "optical battery" for irradiation-free PDT is fabricated by embedding upconversion materials, persistent luminescence materials, photosensitizer into biocompatible polydimethylsiloxane. After 5 s quickly charged by 980-nm NIR laser, the PDT "optical battery" can generate green persistent luminescence and produce cytotoxic singlet oxygen for continuous irradiation-free PDT (∼30 min) without external irradiation. Due to deep tissue penetration and discontinuous short exposure of NIR light charging source, the "optical battery" can still be charged to continuously generate singlet oxygen in deep tissue (∼4 mm) with low photothermal effect. The PDT implant can be easily optimized in size and shape aiming at different nidus sites and achieved different functions by adding other functional components (e.g. CaO2 for oxygen envolving to overcome hypoxia tumor). The effective tumor proliferation inhibiting capability of this NIR rechargeable "optical battery" may give rise to next generation of intelligent stimuli-responsive nanomedicine and noninvasive photo bio-stimulation research for future clinical applications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Prótesis e Implantes Límite: Animals / Female / Humans Idioma: En Revista: Biomaterials Año: 2018 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Prótesis e Implantes Límite: Animals / Female / Humans Idioma: En Revista: Biomaterials Año: 2018 Tipo del documento: Article Pais de publicación: Países Bajos