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Therapeutic Effects of a Traditional Chinese Medicine Formula Plus Tamoxifen vs. Tamoxifen for the Treatment of Mammary Gland Hyperplasia: A Meta-Analysis of Randomized Trials.
Li, Hao-Tian; Liu, Hong-Hong; Yang, Yu-Xue; Wang, Tao; Zhou, Xue-Lin; Yu, Yang; Li, Su-Na; Zheng, Yi; Zhang, Ping; Wang, Rui-Lin; Li, Jian-Yu; Wei, Shi-Zhang; Li, Kun; Li, Peng-Yan; Qian, Li-Qi.
Afiliación
  • Li HT; Department of Pharmacy, 302 Military Hospital of China, Beijing, China.
  • Liu HH; International Center for Liver Disease Treatment, 302 Military Hospital of China, Beijing, China.
  • Yang YX; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Wang T; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Zhou XL; Department of Pharmacy, 302 Military Hospital of China, Beijing, China.
  • Yu Y; Department of Traditional Chinese Medicine, First Affiliated Hospital of Chinese PLA General Hospital, Beijing, China.
  • Li SN; Department of Traditional Chinese Medicine, First Affiliated Hospital of Chinese PLA General Hospital, Beijing, China.
  • Zheng Y; Department of Traditional Chinese Medicine, First Affiliated Hospital of Chinese PLA General Hospital, Beijing, China.
  • Zhang P; Integrative Medical Center, 302 Military Hospital of China, Beijing, China.
  • Wang RL; Integrative Medical Center, 302 Military Hospital of China, Beijing, China.
  • Li JY; Integrative Medical Center, 302 Military Hospital of China, Beijing, China.
  • Wei SZ; Department of Pharmacy, 302 Military Hospital of China, Beijing, China.
  • Li K; Department of Pharmacy, 302 Military Hospital of China, Beijing, China.
  • Li PY; China Military Institute of Chinese Medicine, 302 Military Hospital of China, Beijing, China.
  • Qian LQ; Department of Traditional Chinese Medicine, First Affiliated Hospital of Chinese PLA General Hospital, Beijing, China.
Front Pharmacol ; 9: 45, 2018.
Article en En | MEDLINE | ID: mdl-29456506
As a common disorder that accounts for over 70% of all breast disease cases, mammary gland hyperplasia (MGH) causes a severe problem for the quality of patients' life, and confers an increased risk of breast carcinoma. However, the etiology and pathogenesis of MGH remain unclear, and the safety and efficacy of current western drug therapy for MGH still need to be improved. Therefore, a meta-analysis was conducted by our team to determine whether a TCM formula named Ru-Pi-Xiao in combination with tamoxifen or Ru-Pi-Xiao treated alone can show more prominent therapeutic effects against MGH with fewer adverse reactions than that of tamoxifen. Studies published before June 2017 were searched based on standardized searching rules in several mainstream medical databases. A total of 27 articles with 4,368 patients were enrolled in this meta-analysis. The results showed that the combination of Ru-Pi-Xiao and tamoxifen could exhibit better therapeutic effects against MGH than that of tamoxifen (OR: 3.79; 95% CI: 3.09-4.65; P < 0.00001) with a lower incidence of adverse reactions (OR: 0.35; 95% CI: 0.28-0.43; P < 0.00001). The results also suggested that this combination could improve the level of progesterone (MD: 2.22; 95% CI: 1.72-2.71; P < 0.00001) and decrease the size of breast lump (MD: -0.67; 95% CI: -0.86 to -0.49; P < 0.00001) to a greater extent, which might provide a possible explanation for the pharmacodynamic mechanism of Ru-Pi-Xiao plus tamoxifen. In conclusion, Ru-Pi-Xiao and related preparations could be recommended as auxiliary therapy combined tamoxifen for the treatment of MGH.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Systematic_reviews Idioma: En Revista: Front Pharmacol Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Systematic_reviews Idioma: En Revista: Front Pharmacol Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza