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Humoral response to John Cunningham virus during pregnancy in multiple sclerosis.
Saraste, M; Atula, S; Hedman, K; Hurme, S; Jalkanen, A; Sneck, M; Surcel, H-M; Maghzi, A H; Airas, L.
Afiliación
  • Saraste M; Department of Neurology, University of Turku, Turku, Finland. Electronic address: maija.saraste@utu.fi.
  • Atula S; Clinical Neurosciences, Neurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Hedman K; Department of Virology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Hurme S; Department of Biostatistics, University of Turku, Turku, Finland.
  • Jalkanen A; Division of Clinical Neurosciences, University of Turku and Turku University Hospital, Turku, Finland.
  • Sneck M; HUSLAB, Helsinki University Hospital, Helsinki, Finland.
  • Surcel HM; National Institute for Health and Welfare, Oulu, Finland.
  • Maghzi AH; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
  • Airas L; Division of Clinical Neurosciences, University of Turku and Turku University Hospital, Turku, Finland.
Mult Scler Relat Disord ; 21: 11-18, 2018 Apr.
Article en En | MEDLINE | ID: mdl-29454151
BACKGROUND: Pregnancy induces an immunosuppressive state in the mother to ensure immunological acceptance of the foetus. Impairment of cell-mediated immune responses may render the mother susceptible to intracellular pathogens. It is not presently known whether pregnancy alters the immunosurveillance for John Cunningham virus (JCV), an opportunistic pathogen associated with natalizumab treatment for multiple sclerosis (MS). OBJECTIVE: To evaluate whether the humoral immune response to JCV is altered during pregnancy among MS patients and healthy controls to get insight to potential pregnancy-induced alterations related to immune response to JCV during pregnancy. METHODS: Serum anti-JCV-antibody-indices (JCV-Ab-index) were determined by a two-step second-generation enzyme-linked immunosorbent assay in 49 MS patients during and after pregnancy and in 49 healthy controls during pregnancy. For comparison, total IgG levels and antibodies against Epstein-Barr, cytomegalo and measles viruses were similarly measured. RESULTS: The JCV-Ab-indices of MS patients were not altered during the pregnancy (1st vs. 3rd trimester, 0.62 vs. 0.77, p = 0.99). Contrary to this, in the healthy controls JCV-Ab-indices (p = 0.005), antibody levels to the other viruses, and total IgG levels (p < 0.0001) decreased significantly during pregnancy. CONCLUSIONS: JCV-Ab levels remain unaltered during MS pregnancy, while the total IgG concentration is reduced/diluted due to increasing plasma volumes during the course of pregnancy. This may imply a biologically significant alteration in the immune response to JCV during MS pregnancy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones del Embarazo / Infecciones Tumorales por Virus / Virus JC / Esclerosis Múltiple Recurrente-Remitente / Infecciones por Polyomavirus / Anticuerpos Antivirales Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Mult Scler Relat Disord Año: 2018 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones del Embarazo / Infecciones Tumorales por Virus / Virus JC / Esclerosis Múltiple Recurrente-Remitente / Infecciones por Polyomavirus / Anticuerpos Antivirales Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Mult Scler Relat Disord Año: 2018 Tipo del documento: Article Pais de publicación: Países Bajos