Sustained-release of FGF-2 from a hybrid hydrogel of heparin-poloxamer and decellular matrix promotes the neuroprotective effects of proteins after spinal injury.

Xu, He-Lin; Tian, Fu-Rong; Xiao, Jian; Chen, Pian-Pian; Xu, Jie; Fan, Zi-Liang; Yang, Jing-Jing; Lu, Cui-Tao; Zhao, Ying-Zheng

Xu, He-Lin; Tian, Fu-Rong; Xiao, Jian; Chen, Pian-Pian; Xu, Jie; Fan, Zi-Liang; Yang, Jing-Jing; Lu, Cui-Tao; Zhao, Ying-Zheng.

Afiliación

Xu HL; Department of Pharmaceutics, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou.
Tian FR; Department of Pharmaceutics, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou.
Xiao J; Department of Pharmaceutics, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou.
Chen PP; Department of Pharmaceutics, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou.
Xu J; Department of Pharmaceutics, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou.
Fan ZL; Department of Pharmaceutics, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou.
Yang JJ; Department of Pharmaceutics, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou.
Lu CT; Department of Pharmaceutics, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou.
Zhao YZ; Department of Pharmaceutics, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou.

Int J Nanomedicine ; 13: 681-694, 2018.

Article en En | MEDLINE | ID: mdl-29440894

Asunto(s)

Matriz Extracelular/química; Factor 2 de Crecimiento de Fibroblastos/farmacología; Hidrogel de Polietilenoglicol-Dimetacrilato/farmacología; Fármacos Neuroprotectores/farmacología; Traumatismos de la Médula Espinal/tratamiento farmacológico; Animales; Apoptosis/efectos de los fármacos; Axones/efectos de los fármacos; Preparaciones de Acción Retardada/química; Preparaciones de Acción Retardada/farmacología; Femenino; Factor 2 de Crecimiento de Fibroblastos/farmacocinética; Heparina/química; Hidrogel de Polietilenoglicol-Dimetacrilato/química; Hidrogel de Polietilenoglicol-Dimetacrilato/farmacocinética; Fármacos Neuroprotectores/química; Fármacos Neuroprotectores/farmacocinética; Células PC12; Poloxámero/química; Ratas; Ratas Sprague-Dawley; Médula Espinal/citología; Traumatismos de la Médula Espinal/patología; Temperatura

Palabras clave

adsorption; basic fibroblast growth factor; decellularized extracellular matrix; spinal cord injury; thermosensitive hydrogel

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos de la Médula Espinal / Factor 2 de Crecimiento de Fibroblastos / Fármacos Neuroprotectores / Hidrogel de Polietilenoglicol-Dimetacrilato / Matriz Extracelular Límite: Animals Idioma: En Revista: Int J Nanomedicine Año: 2018 Tipo del documento: Article Pais de publicación: Nueva Zelanda

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