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The capsule of Cryptococcus neoformans.
Casadevall, Arturo; Coelho, Carolina; Cordero, Radames J B; Dragotakes, Quigly; Jung, Eric; Vij, Raghav; Wear, Maggie P.
Afiliación
  • Casadevall A; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health , Baltimore , MD , USA.
  • Coelho C; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health , Baltimore , MD , USA.
  • Cordero RJB; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health , Baltimore , MD , USA.
  • Dragotakes Q; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health , Baltimore , MD , USA.
  • Jung E; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health , Baltimore , MD , USA.
  • Vij R; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health , Baltimore , MD , USA.
  • Wear MP; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health , Baltimore , MD , USA.
Virulence ; 10(1): 822-831, 2019 12.
Article en En | MEDLINE | ID: mdl-29436899
The capsule of Cryptococcus neoformans is its dominant virulence factor and plays a key role in the biology of this fungus. In this essay, we focus on the capsule as a cellular structure and note the limitations inherent in the current methodologies available for its study. Given that no single method can provide the structure of the capsule, our notions of what is the cryptococcal capsule must be arrived at by synthesizing information gathered from very different methodological approaches including microscopy, polysaccharide chemistry and physical chemistry of macromolecules. The emerging picture is one of a carefully regulated dynamic structure that is constantly rearranged as a response to environmental stimulation and cellular replication. In the environment, the capsule protects the fungus against desiccation and phagocytic predators. In animal hosts the capsule functions in both offensive and defensive modes, such that it interferes with immune responses while providing the fungal cell with a defensive shield that is both antiphagocytic and capable of absorbing microbicidal oxidative bursts from phagocytic cells. Finally, we delineate a set of unsolved problems in the cryptococcal capsule field that could provide fertile ground for future investigations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cryptococcus neoformans / Cápsulas Fúngicas Límite: Humans Idioma: En Revista: Virulence Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cryptococcus neoformans / Cápsulas Fúngicas Límite: Humans Idioma: En Revista: Virulence Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos