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Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone.
Gould, Elizabeth A; Busquet, Nicolas; Shepherd, Douglas; Dietz, Robert M; Herson, Paco S; Simoes de Souza, Fabio M; Li, Anan; George, Nicholas M; Restrepo, Diego; Macklin, Wendy B.
Afiliación
  • Gould EA; Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, United States.
  • Busquet N; Rocky Mountain Taste and Smell Center, University of Colorado Anschutz Medical Campus, Aurora, United States.
  • Shepherd D; Neuroscience Program, University of Colorado Anschutz Medical Campus, Aurora, United States.
  • Dietz RM; Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora, United States.
  • Herson PS; Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, United States.
  • Simoes de Souza FM; Pediatric Heart Lung Center, University of Colorado Anschutz Medical Campus, Aurora, United States.
  • Li A; Department of Anesthesiology, University of Colorado School of Medicine, Aurora, United States.
  • George NM; Department of Anesthesiology, University of Colorado School of Medicine, Aurora, United States.
  • Restrepo D; Center of Mathematics, Computation and Cognition, Federal University of ABC, Brazil.
  • Macklin WB; Jiangsu Key Laboratory of Brain Disease and Bioinformation, Research Center for Biochemistry and Molecular Biology, Xuzhou Medical University, Xuzhou, China.
Elife ; 72018 02 13.
Article en En | MEDLINE | ID: mdl-29436368
Myelin, the insulating sheath around axons, supports axon function. An important question is the impact of mild myelin disruption. In the absence of the myelin protein proteolipid protein (PLP1), myelin is generated but with age, axonal function/maintenance is disrupted. Axon disruption occurs in Plp1-null mice as early as 2 months in cortical projection neurons. High-volume cellular quantification techniques revealed a region-specific increase in oligodendrocyte density in the olfactory bulb and rostral corpus callosum that increased during adulthood. A distinct proliferative response of progenitor cells was observed in the subventricular zone (SVZ), while the number and proliferation of parenchymal oligodendrocyte progenitor cells was unchanged. This SVZ proliferative response occurred prior to evidence of axonal disruption. Thus, a novel SVZ response contributes to the region-specific increase in oligodendrocytes in Plp1-null mice. Young adult Plp1-null mice exhibited subtle but substantial behavioral alterations, indicative of an early impact of mild myelin disruption.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Axones / Conducta Animal / Proteína Proteolipídica de la Mielina / Ventrículos Laterales / Vaina de Mielina Límite: Animals Idioma: En Revista: Elife Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Axones / Conducta Animal / Proteína Proteolipídica de la Mielina / Ventrículos Laterales / Vaina de Mielina Límite: Animals Idioma: En Revista: Elife Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido