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Environmental manganese exposure and associations with memory, executive functions, and hyperactivity in Brazilian children.
Carvalho, Chrissie Ferreira de; Oulhote, Youssef; Martorelli, Marina; Carvalho, Carla Oliveira de; Menezes-Filho, José Antônio; Argollo, Nayara; Abreu, Neander.
Afiliación
  • Carvalho CF; Federal University of Bahia - Psychology Institute, Brazil. Electronic address: chrissieca@gmail.com.
  • Oulhote Y; Harvard University - Harvard T. H. Chan School of Public Health, USA.
  • Martorelli M; Federal University of Bahia - Psychology Institute, Brazil.
  • Carvalho CO; Federal University of Bahia - Psychology Institute, Brazil.
  • Menezes-Filho JA; Federal University of Bahia - College of Pharmacy, Brazil.
  • Argollo N; Federal University of Bahia - College of Medicine, Brazil.
  • Abreu N; Federal University of Bahia - Psychology Institute, Brazil.
Neurotoxicology ; 69: 253-259, 2018 12.
Article en En | MEDLINE | ID: mdl-29432852
Manganese (Mn) is an essential element, however high levels of Mn have been associated with lower neuropsychological performance and behavioral problems in children. We investigated the associations between hair Mn concentrations and neuropsychological and behavioral performances among children with long-term exposure to airborne Mn aged between 7 and 12 years. Neuropsychological performance included tests of: verbal memory, inhibitory control, cognitive flexibility, verbal fluency, and motor function. We used the Conners Abbreviated Rating Scale for teachers to assess students' behaviors of hyperactivity. Hair manganese (MnH) concentrations in children and exposure to airborne manganese from a ferro-manganese alloy plant were analyzed and correlated with tests scores. Multivariable linear models adjusting for potential confounders showed that elevated levels of MnH were associated with lower performance in verbal memory, as measured by the free recall after interference (ß = - 1.8; 95% CI: - 3.4, - 0.2), which indicates susceptibility to interference, and Delayed Effect (ß = -2.0; 95% CI: -3.7, - 0.2), representing a loss of information over time. Additionally, we found patterns of effect modification by sex in three subtests measuring verbal memory: the free recall after interference score, Interference Effect, and Delayed Effect (all at p < 0.10). Overall, the results suggest that long-term airborne Mn exposure may be associated with lower performance in verbal memory, and hyperactivity behaviors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aprendizaje Verbal / Función Ejecutiva / Hipercinesia / Manganeso / Memoria Tipo de estudio: Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Female / Humans / Male País/Región como asunto: America do sul / Brasil Idioma: En Revista: Neurotoxicology Año: 2018 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aprendizaje Verbal / Función Ejecutiva / Hipercinesia / Manganeso / Memoria Tipo de estudio: Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Female / Humans / Male País/Región como asunto: America do sul / Brasil Idioma: En Revista: Neurotoxicology Año: 2018 Tipo del documento: Article Pais de publicación: Países Bajos