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Cognitive impairment in early onset epilepsy is associated with reduced left thalamic volume.
Yoong, Michael; Hunter, Matthew; Stephen, Jacqueline; Quigley, Alan; Jones, Jeremy; Shetty, Jay; McLellan, Ailsa; Bastin, Mark E; Chin, Richard F M.
Afiliación
  • Yoong M; Muir Maxwell Epilepsy Centre, University of Edinburgh, UK; Department of Paediatric Neurology, Royal Hospital for Sick Children, Edinburgh, UK. Electronic address: michael.yoong@ed.ac.uk.
  • Hunter M; Muir Maxwell Epilepsy Centre, University of Edinburgh, UK.
  • Stephen J; Edinburgh Clinical Trials Unit, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, UK.
  • Quigley A; Department of Radiology, Royal Hospital for Sick Children, Edinburgh, UK.
  • Jones J; Department of Radiology, Royal Hospital for Sick Children, Edinburgh, UK.
  • Shetty J; Department of Paediatric Neurology, Royal Hospital for Sick Children, Edinburgh, UK.
  • McLellan A; Department of Paediatric Neurology, Royal Hospital for Sick Children, Edinburgh, UK.
  • Bastin ME; Muir Maxwell Epilepsy Centre, University of Edinburgh, UK; Brain Research Imaging Centre, University of Edinburgh, UK.
  • Chin RFM; Muir Maxwell Epilepsy Centre, University of Edinburgh, UK; Department of Paediatric Neurology, Royal Hospital for Sick Children, Edinburgh, UK.
Epilepsy Behav ; 80: 266-271, 2018 03.
Article en En | MEDLINE | ID: mdl-29422396
OBJECTIVE: The objective of this study was to investigate whether reduction of thalamic volumes in children with early onset epilepsy (CWEOE) is associated with cognitive impairment. METHODS: This is a nested case-control study including a prospectively recruited cohort of 76 children with newly-diagnosed early onset epilepsy (onset <5years age) and 14 healthy controls presenting to hospitals within NHS Lothian and Fife. Quantitative volumetric analysis of subcortical structures was performed using volumetric T1-weighted magnetic resonance imaging (MRI) and correlated with the results of formal neurocognitive and clinical assessment. False discovery rate was used to correct for multiple comparisons as appropriate with q<0.05 used to define statistical significance. RESULTS: Age, gender, and intracranial volume (ICV)-adjusted left thalamic volumes were significantly reduced in CWEOE with cognitive impairment compared to CWEOE without impairment (5295mm3 vs 6418mm3, q=0.008) or healthy controls (5295mm3 vs 6410mm3, q<0.001). The differences in left thalamic volume remained if gray matter or cortical/cerebellar volumes were used as covariates rather than ICV (q<0.05). The degree of volume reduction correlated with the severity of cognitive impairment (q=0.048). SIGNIFICANCE: Reduced left thalamic volume may be a biomarker for cognitive impairment in CWEOE and could help inform the need for further formal cognitive evaluations and interventions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tálamo / Encéfalo / Imagen por Resonancia Magnética / Cognición / Epilepsia / Disfunción Cognitiva Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Child / Female / Humans / Male Idioma: En Revista: Epilepsy Behav Asunto de la revista: CIENCIAS DO COMPORTAMENTO / NEUROLOGIA Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tálamo / Encéfalo / Imagen por Resonancia Magnética / Cognición / Epilepsia / Disfunción Cognitiva Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Child / Female / Humans / Male Idioma: En Revista: Epilepsy Behav Asunto de la revista: CIENCIAS DO COMPORTAMENTO / NEUROLOGIA Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos