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QT-interval evaluation in primary percutaneous coronary intervention of ST-segment elevation myocardial infarction for prediction of myocardial salvage index.
Guaricci, Andrea Igoren; Carità, Patrizia; Lorenzoni, Valentina; Casavecchia, GraziaPia; Rabbat, Mark; Ieva, Riccardo; Brunetti, Natale Daniele; Andreini, Daniele; Di Biase, Matteo; Marenzi, Giancarlo; Bartorelli, Antonio; Pepi, Mauro; Pontone, Gianluca.
Afiliación
  • Guaricci AI; Institute of Cardiovascular Disease, Department of Emergency and Organ Transplantation, University Hospital "Policlinico" of Bari, Bari, Italy.
  • Carità P; Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
  • Lorenzoni V; Department of Cardiology, University Hospital P. Giaccone, Palermo, Italy.
  • Casavecchia G; Scuola Superiore Sant'Anna, Firenze, Italy.
  • Rabbat M; Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
  • Ieva R; Loyola University of Chicago, Chicago, Illinois, United States of America.
  • Brunetti ND; Edward Hines Jr. VA Hospital, Hines, Illinois, United States of America.
  • Andreini D; Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
  • Di Biase M; Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
  • Marenzi G; Centro Cardiologico Monzino, IRCCS, Milan, Italy.
  • Bartorelli A; Department of Cardiovascular Sciences and Community Health, University of Milan, Milan, Italy.
  • Pepi M; Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
  • Pontone G; Centro Cardiologico Monzino, IRCCS, Milan, Italy.
PLoS One ; 13(2): e0192220, 2018.
Article en En | MEDLINE | ID: mdl-29420570
Assessing the efficacy of revascularization therapy in patients with ST-segment elevation myocardial infarction (STEMI) is extremely important in order to guide subsequent management and assess prognosis. We aimed to determine the relationship between corrected QT-interval (QTc) changes on standard sequential ECG and myocardial salvage index in anterior STEMI patients after successful primary percutaneous coronary intervention. Fifty anterior STEMI patients treated by primary percutaneous coronary intervention underwent quantitative ECG analysis and cardiac magnetic resonance. For each patient the difference (ΔQTc) between the QTc of ischemic myocardium (maximum QTc in anterior leads) versus remote myocardium (minimum QTc in inferior leads) during the first six days after STEMI was measured. The QTc in anterior leads was significantly longer than QTc in inferior leads (p<0.0001). At multivariate analysis, ΔQTC and peak troponin I were the only independent predictors for late gadolium enhancement while ΔQTc and left ventricular ejection fraction were independent predictors of myocardial salvage index <60%. The receiver operative curve of ΔQTc showed an area under the curve of 0.77 to predict a myocardial salvage index <0.6. In conclusion, in a subset of patients with a first occurrence of early revascularized anterior STEMI, ΔQTc is inversely correlated with CMR-derived myocardial salvage index and may represent a useful parameter for assessing efficacy of reperfusion therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Intervención Coronaria Percutánea / Infarto del Miocardio con Elevación del ST / Infarto del Miocardio Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2018 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Intervención Coronaria Percutánea / Infarto del Miocardio con Elevación del ST / Infarto del Miocardio Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2018 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos