Your browser doesn't support javascript.
loading
Translation control of mRNAs encoding mammalian translation initiation factors.
Andreev, Dmitri E; Dmitriev, Sergey E; Loughran, Gary; Terenin, Ilya M; Baranov, Pavel V; Shatsky, Ivan N.
Afiliación
  • Andreev DE; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia. Electronic address: cycloheximide@yandex.ru.
  • Dmitriev SE; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia; Department of Biochemistry, Biological Faculty, Lomonosov Moscow State University, Moscow, Russia.
  • Loughran G; School of Biochemistry and Cell Biology, University College Cork, Cork, Ireland.
  • Terenin IM; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
  • Baranov PV; School of Biochemistry and Cell Biology, University College Cork, Cork, Ireland.
  • Shatsky IN; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia. Electronic address: shatsky@genebee.msu.su.
Gene ; 651: 174-182, 2018 Apr 20.
Article en En | MEDLINE | ID: mdl-29414693
Eukaryotic cells evolved highly complex and accurate protein synthesis machinery that is finely tuned by various signaling pathways. Dysregulation of translation is a hallmark of many diseases, including cancer, and thus pharmacological approaches to modulate translation become very promising. While there has been much progress in our understanding of mammalian mRNA-specific translation control, surprisingly, relatively little is known about whether and how the protein components of the translation machinery shape translation of their own mRNAs. Here we analyze mammalian mRNAs encoding components of the translation initiation machinery for potential regulatory features such as 5'TOP motifs, TISU motifs, poor start codon nucleotide context and upstream open reading frames.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN Mensajero / Regulación de la Expresión Génica / Factores Eucarióticos de Iniciación Límite: Animals / Humans Idioma: En Revista: Gene Año: 2018 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN Mensajero / Regulación de la Expresión Génica / Factores Eucarióticos de Iniciación Límite: Animals / Humans Idioma: En Revista: Gene Año: 2018 Tipo del documento: Article Pais de publicación: Países Bajos