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Integrins in wound healing, fibrosis and tumor stroma: High potential targets for therapeutics and drug delivery.
Schnittert, Jonas; Bansal, Ruchi; Storm, Gert; Prakash, Jai.
Afiliación
  • Schnittert J; Section - Targeted Therapeutics, Department of Biomaterials Science and Technology, University of Twente, Enschede, The Netherlands.
  • Bansal R; Section - Targeted Therapeutics, Department of Biomaterials Science and Technology, University of Twente, Enschede, The Netherlands.
  • Storm G; Section - Targeted Therapeutics, Department of Biomaterials Science and Technology, University of Twente, Enschede, The Netherlands; Department of Pharmaceutics, Utrecht University, Utrecht, The Netherlands.
  • Prakash J; Section - Targeted Therapeutics, Department of Biomaterials Science and Technology, University of Twente, Enschede, The Netherlands; ScarTec Therapeutics BV, Enschede, The Netherlands. Electronic address: j.prakash@utwente.nl.
Adv Drug Deliv Rev ; 129: 37-53, 2018 04.
Article en En | MEDLINE | ID: mdl-29414674
Wound healing is a complex process, which ultimately leads to fibrosis if not repaired well. Pathologically very similar to fibrosis is the tumor stroma, found in several solid tumors which are regarded as wounds that do not heal. Integrins are heterodimeric surface receptors which control various physiological cellular functions. Additionally, integrins also sense ECM-induced extracellular changes during pathological events, leading to cellular responses, which influence ECM remodeling. The purpose and scope of this review is to introduce integrins as key targets for therapeutics and drug delivery within the scope of wound healing, fibrosis and the tumor stroma. This review provides a general introduction to the biology of integrins including their types, ligands, means of signaling and interaction with growth factor receptors. Furthermore, we highlight integrins as key targets for therapeutics and drug delivery, based on their biological role, expression pattern within human tissues and at cellular level. Next, therapeutic approaches targeting integrins, with a focus on clinical studies, and targeted drug delivery strategies based on ligands are described.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cicatrización de Heridas / Sistemas de Liberación de Medicamentos / Células del Estroma / Neoplasias / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Adv Drug Deliv Rev Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2018 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cicatrización de Heridas / Sistemas de Liberación de Medicamentos / Células del Estroma / Neoplasias / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Adv Drug Deliv Rev Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2018 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Países Bajos