Black and white teas as potential agents to combine with amphotericin B and protect red blood cells from amphotericin B-mediated toxicity.

Oliveira, V M; Khalil, N M; Carraro, E

Oliveira, V M; Khalil, N M; Carraro, E.

Afiliación

Oliveira VM; Laboratório de Virologia, Programa de Pós-graduação em Ciências Farmacêuticas, Departamento de Farmácia, Universidade Estadual do Centro-Oeste - UNICENTRO, Rua Simeão Camargo Varelá de Sá, nº 3, CEP 85040-080, Guarapuava, PR, Brazil.
Khalil NM; Laboratório de Nanotecnologia Farmacêutica, Programa de Pós-graduação em Ciências Farmacêuticas, Departamento de Farmácia, Universidade Estadual do Centro-Oeste - UNICENTRO, Rua Simeão Camargo Varelá de Sá, nº 3, CEP 85040-080, Guarapuava, PR, Brazil.
Carraro E; Laboratório de Virologia, Programa de Pós-graduação em Ciências Farmacêuticas, Departamento de Farmácia, Universidade Estadual do Centro-Oeste - UNICENTRO, Rua Simeão Camargo Varelá de Sá, nº 3, CEP 85040-080, Guarapuava, PR, Brazil.

Braz J Biol ; 78(4): 673-678, 2018 Nov.

Article en En | MEDLINE | ID: mdl-29412247

RESUMEN

Amphotericin B is a fungicidal substance that is treatment of choice for most systemic fungal infections affecting immunocompromised patients. However, severe side effects have limited the utility of this drug. The aim of this study was to evaluate the antifungal effect of the combination of amphotericin B with black tea or white tea and protective of citotoxic effect. The present study shows that white and black teas have additive effects with amphotericin B against some species Candida. In addition, the combination of white and black tea with amphotericin B may reduce the toxicity of amphotericin B to red blood cells. Our results suggest that white and black tea is a potential agent to combine with amphotericin for antifungal efficacy and to reduce the amphotericin dose to lessen side effects.

Asunto(s)

Anfotericina B/farmacología; Antifúngicos/farmacología; Camellia sinensis/efectos de los fármacos; Candida/efectos de los fármacos; Eritrocitos/efectos de los fármacos; Anfotericina B/efectos adversos; Antifúngicos/efectos adversos; Hemólisis/efectos de los fármacos; Humanos

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Candida / Anfotericina B / Camellia sinensis / Eritrocitos / Antifúngicos Límite: Humans Idioma: En Revista: Braz J Biol Asunto de la revista: BIOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil

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