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The beneficial role of exercise in mitigating doxorubicin-induced Mitochondrionopathy.
Marques-Aleixo, I; Santos-Alves, E; Oliveira, P J; Moreira, P I; Magalhães, J; Ascensão, A.
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  • Marques-Aleixo I; CIAFEL - Research Centre in Physical Activity, Health and Leisure, Portugal; LAMETEX - Laboratory of Exercise and Metabolism; Faculty of Psychology, Education and Sport, University Lusófona of Porto, Portugal. Electronic address: ines.aleixo@ulp.pt.
  • Santos-Alves E; CIAFEL - Research Centre in Physical Activity, Health and Leisure, Portugal; LAMETEX - Laboratory of Exercise and Metabolism; Departament de Biologia Cellular, Fisiologia i Immunologia, Facultat de Biologia, Universitat de Barcelona, Spain.
  • Oliveira PJ; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, UC Biotech Building, Biocant Park, Cantanhede, Portugal.
  • Moreira PI; CNC - Centre for Neuroscience and Cell Biology, University of Coimbra, Portugal; Institute of Physiology, Faculty of Medicine, University of Coimbra, Portugal.
  • Magalhães J; CIAFEL - Research Centre in Physical Activity, Health and Leisure, Portugal; LAMETEX - Laboratory of Exercise and Metabolism; Faculty of Sport, University of Porto, Portugal.
  • Ascensão A; CIAFEL - Research Centre in Physical Activity, Health and Leisure, Portugal; LAMETEX - Laboratory of Exercise and Metabolism; Faculty of Sport, University of Porto, Portugal.
Biochim Biophys Acta Rev Cancer ; 1869(2): 189-199, 2018 Apr.
Article en En | MEDLINE | ID: mdl-29408395
Doxorubicin (DOX) is a widely used antineoplastic agent for a wide range of cancers, including hematological malignancies, soft tissue sarcomas and solid tumors. However, DOX exhibits a dose-related toxicity that results in life-threatening cardiomyopathy. In addition to the heart, there is evidence that DOX toxicity extends to other organs. This general toxicity seems to be related to mitochondrial network structural, molecular and functional impairments. Several countermeasures for these negative effects have been proposed, being physical exercise, not only one of the most effective non-pharmacologic strategy but also widely recommended as booster against cancer-related fatigue. It is widely accepted that mitochondria are critical sensors of tissue functionality, both modulated by DOX and exercise. Therefore, this review focuses on the current understanding of the mitochondrial-mediated mechanisms underlying the protective effect of exercise against DOX-induced toxicity, not only limited to the cardiac tissue, but also in other tissues such as skeletal muscle, liver and brain. We here analyze recent developments regarding the beneficial effects of exercise targeting mitochondrial responsive phenotypes against redox changes, mitochondrial bioenergetics, apoptotic, dynamics and quality control signalling affected by DOX treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Doxorrubicina / Músculo Esquelético / Enfermedades Mitocondriales / Miocitos Cardíacos / Terapia por Ejercicio / Mitocondrias Cardíacas / Antibióticos Antineoplásicos / Enfermedades Musculares / Cardiomiopatías Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Biochim Biophys Acta Rev Cancer Año: 2018 Tipo del documento: Article Pais de publicación: Países Bajos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Doxorrubicina / Músculo Esquelético / Enfermedades Mitocondriales / Miocitos Cardíacos / Terapia por Ejercicio / Mitocondrias Cardíacas / Antibióticos Antineoplásicos / Enfermedades Musculares / Cardiomiopatías Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Biochim Biophys Acta Rev Cancer Año: 2018 Tipo del documento: Article Pais de publicación: Países Bajos