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Impact of sleep disorders on the risk of seizure recurrence in juvenile myoclonic epilepsy.
Buratti, Laura; Natanti, Alice; Viticchi, Giovanna; Falsetti, Lorenzo; Lattanzi, Simona; Pulcini, Alessandra; Petrelli, Cristina; Provinciali, Leandro; Silvestrini, Mauro.
Afiliación
  • Buratti L; Neurological Clinic, Marche Polytechnic University, Ancona, Italy.
  • Natanti A; Neurological Clinic, Marche Polytechnic University, Ancona, Italy.
  • Viticchi G; Neurological Clinic, Marche Polytechnic University, Ancona, Italy.
  • Falsetti L; Internal and Subintensive Medicine, Ospedali Riuniti Ancona, Italy.
  • Lattanzi S; Neurological Clinic, Marche Polytechnic University, Ancona, Italy.
  • Pulcini A; Neurological Clinic, Marche Polytechnic University, Ancona, Italy.
  • Petrelli C; Neurological Clinic, Marche Polytechnic University, Ancona, Italy.
  • Provinciali L; Neurological Clinic, Marche Polytechnic University, Ancona, Italy.
  • Silvestrini M; Neurological Clinic, Marche Polytechnic University, Ancona, Italy. Electronic address: m.silvestrini@univpm.it.
Epilepsy Behav ; 80: 21-24, 2018 03.
Article en En | MEDLINE | ID: mdl-29396358
OBJECTIVE: The aim of this study was to investigate the presence of sleep disturbances in patients with juvenile myoclonic epilepsy (JME) using sleep questionnaires. Further, we tried to evaluate whether alterations in sleep quality may influence the clinical expression of JME. METHODS: Sixty-two patients with JME treated with levetiracetam were included. Demographic and clinical variables were collected. Moreover, all patients submitted the Pittsburgh Sleep Quality index (PSQI) and the Epworth Sleepiness Scale (ESS) in order to respectively assess sleep quality during the last month and daytime sleepiness. All patients were followed up for a 6-month period and divided in two groups: seizure-free (Group 1) and seizure recurrence (Group 2). The PSQI and ESS scores were synthesized as binary variables <5/≥5 and <10/≥10, respectively. A comprehensive analysis was performed to evaluate the independent effect of the sleep quality and daytime sleepiness on the risk of having seizures during the follow-up. RESULTS: Both reduced sleep quality during the last month and daytime sleepiness were associated with an increased risk of suffering from seizures during the follow-up period. In fact, a PSQI score<5 or an ESS score<10 resulted significantly associated with the absence of seizure recurrence (p<0.004 and p<0.001, respectively). Increasing age had a significantly protective effect in the risk of seizure relapse. CONCLUSIONS: Our findings show that reduced sleep quality and daytime sleepiness in patients with JME increase the risk of seizure occurrence in spite of an appropriate pharmacological treatment. This negative effect seems to be more relevant in younger patients. Sleep disorders and their specific correction should be taken into consideration for the management of patients with JME.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Convulsiones / Sueño / Trastornos del Sueño-Vigilia / Epilepsia Mioclónica Juvenil / Somnolencia Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Epilepsy Behav Asunto de la revista: CIENCIAS DO COMPORTAMENTO / NEUROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Convulsiones / Sueño / Trastornos del Sueño-Vigilia / Epilepsia Mioclónica Juvenil / Somnolencia Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Epilepsy Behav Asunto de la revista: CIENCIAS DO COMPORTAMENTO / NEUROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos