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Factors influencing health-related quality of life in patients with Type 1 diabetes.
Raymakers, A J N; Gillespie, P; O'Hara, M C; Griffin, M D; Dinneen, S F.
Afiliación
  • Raymakers AJN; CÚRAM Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland. adam.raymakers@nuigalway.ie.
  • Gillespie P; Health Economics and Policy Analysis Centre, National University of Ireland Galway, Galway, Ireland. adam.raymakers@nuigalway.ie.
  • O'Hara MC; CÚRAM Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland.
  • Griffin MD; Health Economics and Policy Analysis Centre, National University of Ireland Galway, Galway, Ireland.
  • Dinneen SF; Research and Development, Health Services Executive, Health and Wellbeing Division, Galway, Ireland.
Health Qual Life Outcomes ; 16(1): 27, 2018 Feb 02.
Article en En | MEDLINE | ID: mdl-29394942
AIMS: Generic, preference-based measures of health-related quality of life (HRQoL) are a common input to the economic evaluation of new health technologies. As such, it is important to explore what characteristics of patients with Type 1 diabetes might impact scores on such measures. METHODS: This study utilizes baseline data from a cluster-randomized trial that recruited patients with Type 1 diabetes at six centers across Ireland. Health-related quality of life was assessed using the three-level EuroQol EQ-5D (EQ-5D) measure. Patients' responses to individual dimensions of the EQ-5D were explored. To see which patient factors influenced EQ-5D scores, multivariate regression analysis was conducted with EQ-5D scores as the outcome variable. RESULTS: Data was available for 437 Type 1 diabetes patients. The median age of these patients was 40 (IQR: 31-49) years and 53.8% were female. Overall, patients reported a high HRQoL based on EQ-5D scores (0.87 (SD: 0.19). Fifty-four percent of patients reported a perfect HRQoL. For those that reported problems, the most common dimension was the anxiety/depression dimension of the EQ-5D (29.6%). In the multivariate regression analysis, self-reported mental illness (- 0.22 (95% CI: -0.34, - 0.10)) and being unemployed (- 0.07 (95% CI: -0.13, - 0.02)) were negatively associated with EQ-5D scores (p < 0.05). The influence of self-reported mental illness was persistent in sensitivity analyses. CONCLUSIONS: The study results indicate that patients with Type 1 diabetes report a high HRQoL based on responses to the EQ-5D. However, there are a substantial number of Type 1 diabetes patients that report problems in the anxiety/depression dimension, which may provide avenues to improve patients' HRQoL. TRIAL REGISTRATION: Current Controlled Trials ISRCTN79759174 .
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Calidad de Vida / Diabetes Mellitus Tipo 1 Tipo de estudio: Clinical_trials Aspecto: Patient_preference Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Health Qual Life Outcomes Asunto de la revista: SAUDE PUBLICA Año: 2018 Tipo del documento: Article País de afiliación: Irlanda Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Calidad de Vida / Diabetes Mellitus Tipo 1 Tipo de estudio: Clinical_trials Aspecto: Patient_preference Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Health Qual Life Outcomes Asunto de la revista: SAUDE PUBLICA Año: 2018 Tipo del documento: Article País de afiliación: Irlanda Pais de publicación: Reino Unido