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Molecular changes associated with increased TNF-α-induced apoptotis in naïve (TN) and central memory (TCM) CD8+ T cells in aged humans.
Gupta, Sudhir; Su, Houfen; Agrawal, Sudhanshu; Gollapudi, Sastry.
Afiliación
  • Gupta S; 1Program in Primary Immunodeficiency and Aging, Division of Basic and Clinical Immunology, University of California, Irvine, USA.
  • Su H; 2Division of Basic and Clinical Immunology, Medical Sci. I, C-240, University of California at Irvine, Irvine, CA 92697 USA.
  • Agrawal S; 1Program in Primary Immunodeficiency and Aging, Division of Basic and Clinical Immunology, University of California, Irvine, USA.
  • Gollapudi S; 1Program in Primary Immunodeficiency and Aging, Division of Basic and Clinical Immunology, University of California, Irvine, USA.
Immun Ageing ; 15: 2, 2018.
Article en En | MEDLINE | ID: mdl-29387134
BACKGROUND: Progressive T cell decline in aged humans is associated with a deficiency of naïve (TN) and central memory (TCM) T cells. We have previously reported increased Tumor necrosis factor-α (TNF-α)-induced apoptosis in TN and TCM T cells in aged humans; however, the molecular basis of increased apoptosis remains to be defined. Since expression of TNF receptors (TNFRs) was reported to be comparable in young and aged, we investigated signaling events downstream of TNFRs to understand the molecular basis of increased TNF-α-induced apoptosis in aged TN and TCM CD8+ cells. RESULTS: The expression of TRAF-2 and RIP, phosphorylation of JNK, IKKα/ß, and IκBα, and activation of NF-κB activation were significantly decreased in TN and TCM CD8+ cells from aged subjects as compared to young controls. Furthermore, expression of A20, Bcl-xL, cIAP1, and FLIP-L and FLIP-S was significantly decreased in TN and TCM CD8+ cells from aged subjects. CONCLUSIONS: These data demonstrate that an impaired expression/function of molecules downstream TNFR signaling pathway that confer survival signals contribute to increased apoptosis of TN and TCM CD8+ cells in aged humans.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Immun Ageing Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Immun Ageing Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido