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Heterogeneity within the frontoparietal control network and its relationship to the default and dorsal attention networks.
Dixon, Matthew L; De La Vega, Alejandro; Mills, Caitlin; Andrews-Hanna, Jessica; Spreng, R Nathan; Cole, Michael W; Christoff, Kalina.
Afiliación
  • Dixon ML; Department of Psychology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; mattdixon99@gmail.com kchristoff@psych.ubc.ca.
  • De La Vega A; Department of Psychology, University of Texas at Austin, Austin, TX 78712.
  • Mills C; Department of Psychology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
  • Andrews-Hanna J; Institute of Cognitive Science, University of Colorado at Boulder, Boulder, CO 80309-0345.
  • Spreng RN; Laboratory of Brain and Cognition, Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, QC H3A 2B4, Canada.
  • Cole MW; Human Neuroscience Institute, Department of Human Development, Cornell University, Ithaca, NY 14853-7601.
  • Christoff K; Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 08854.
Proc Natl Acad Sci U S A ; 115(7): E1598-E1607, 2018 02 13.
Article en En | MEDLINE | ID: mdl-29382744
The frontoparietal control network (FPCN) plays a central role in executive control. It has been predominantly viewed as a unitary domain general system. Here, we examined patterns of FPCN functional connectivity (FC) across multiple conditions of varying cognitive demands, to test for FPCN heterogeneity. We identified two distinct subsystems within the FPCN based on hierarchical clustering and machine learning classification analyses of within-FPCN FC patterns. These two FPCN subsystems exhibited distinct patterns of FC with the default network (DN) and the dorsal attention network (DAN). FPCNA exhibited stronger connectivity with the DN than the DAN, whereas FPCNB exhibited the opposite pattern. This twofold FPCN differentiation was observed across four independent datasets, across nine different conditions (rest and eight tasks), at the level of individual-participant data, as well as in meta-analytic coactivation patterns. Notably, the extent of FPCN differentiation varied across conditions, suggesting flexible adaptation to task demands. Finally, we used meta-analytic tools to identify several functional domains associated with the DN and DAN that differentially predict activation in the FPCN subsystems. These findings reveal a flexible and heterogeneous FPCN organization that may in part emerge from separable DN and DAN processing streams. We propose that FPCNA may be preferentially involved in the regulation of introspective processes, whereas FPCNB may be preferentially involved in the regulation of visuospatial perceptual attention.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Función Ejecutiva / Lóbulo Frontal Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Función Ejecutiva / Lóbulo Frontal Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos