The small heat shock protein Hsp27 binds &#945;-synuclein fibrils, preventing elongation and cytotoxicity.

Cox, Dezerae; Whiten, Daniel R; Brown, James W P; Horrocks, Mathew H; San Gil, Rebecca; Dobson, Christopher M; Klenerman, David; van Oijen, Antoine M; Ecroyd, Heath

The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity.

Cox, Dezerae; Whiten, Daniel R; Brown, James W P; Horrocks, Mathew H; San Gil, Rebecca; Dobson, Christopher M; Klenerman, David; van Oijen, Antoine M; Ecroyd, Heath.

Afiliación

Cox D; From the Illawarra Health and Medical Research Institute and.
Whiten DR; School of Biological Sciences, University of Wollongong, Wollongong, New South Wales, 2522, Australia.
Brown JWP; From the Illawarra Health and Medical Research Institute and.
Horrocks MH; School of Biological Sciences, University of Wollongong, Wollongong, New South Wales, 2522, Australia.
San Gil R; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom, and.
Dobson CM; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom, and.
Klenerman D; From the Illawarra Health and Medical Research Institute and.
van Oijen AM; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom, and.
Ecroyd H; From the Illawarra Health and Medical Research Institute and.

J Biol Chem ; 293(12): 4486-4497, 2018 03 23.

Article en En | MEDLINE | ID: mdl-29382725

Asunto(s)

Proteínas de Choque Térmico HSP27/metabolismo; Neuroblastoma/patología; Agregado de Proteínas; alfa-Sinucleína/metabolismo; Animales; Proteínas de Choque Térmico HSP27/genética; Proteínas de Choque Térmico; Humanos; Ratones; Chaperonas Moleculares; Neuroblastoma/metabolismo; Células Tumorales Cultivadas; alfa-Sinucleína/genética

Palabras clave

Lewy body dementia; Parkinson's disease; alpha-synuclein; alpha-synucleinopathy; amyloid; molecular chaperone; neurodegeneration; neurodegenerative disease; protein aggregation; sHsp; small heat shock protein; α-synuclein; α-synucleinopathy

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alfa-Sinucleína / Proteínas de Choque Térmico HSP27 / Agregado de Proteínas / Neuroblastoma Límite: Animals / Humans Idioma: En Revista: J Biol Chem Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos

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