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Component-resolved diagnostics demonstrates that most peanut-allergic individuals could potentially introduce tree nuts to their diet.
Uotila, R; Kukkonen, A K; Blom, W M; Remington, B; Westerhout, J; Pelkonen, A S; Mäkelä, M J.
Afiliación
  • Uotila R; Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
  • Kukkonen AK; Skin and Allergy Hospital, Helsinki, Finland.
  • Blom WM; Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
  • Remington B; Skin and Allergy Hospital, Helsinki, Finland.
  • Westerhout J; The Netherlands Organisation for Applied Scientific Research (TNO), Zeist, The Netherlands.
  • Pelkonen AS; The Netherlands Organisation for Applied Scientific Research (TNO), Zeist, The Netherlands.
  • Mäkelä MJ; The Netherlands Organisation for Applied Scientific Research (TNO), Zeist, The Netherlands.
Clin Exp Allergy ; 48(6): 712-721, 2018 06.
Article en En | MEDLINE | ID: mdl-29377469
BACKGROUND: Nut allergy varies from pollen cross-allergy, to primary severe allergy with life-threatening symptoms. The screening of IgE antibodies to a wide spectrum of allergens, including species-specific and cross-reactive allergens, is made possible via microarray analysis. OBJECTIVE: We sought to study the association of variable IgE sensitization profiles to clinical response in peanut-challenged children and adolescents in a birch-endemic region. In addition, we studied the avoidance of tree nuts and species-specific sensitizations. METHODS: We studied 102 peanut-sensitized patients who underwent a double-blind placebo-controlled challenge to peanut. We analysed ISAC ImmunoCAP microarray to 112 allergens, singleplex ImmunoCAPs for hazelnut Cor a 14 and cashew Ana o 3, and performed skin prick tests to peanut, tree nuts and sesame seed. We surveyed avoidance diets with a questionnaire. RESULTS: Sensitization to PR-10 proteins was frequent (Bet v 1 90%), but equally high in the challenge negatives and positives. IgE to Ara h 2 and Ara h 6 discriminated peanut allergic (n = 69) and tolerant (n = 33) the best. Avoidance of tree nuts was common (52% to 96%), but only 6% to 44% presented species-specific sensitizations to tree nuts, so a great number could potentially introduce these species into their diet. CONCLUSIONS AND CLINICAL RELEVANCE: PR-10-sensitizations were frequent and strong regardless of peanut allergy status. Component-resolved diagnostics can be employed to demonstrate to patients that sensitization to seed storage proteins of tree nuts is uncommon. Several tree nuts could potentially be reintroduced to the diet.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arachis / Hipersensibilidad al Cacahuete / Dieta / Nueces Tipo de estudio: Clinical_trials / Diagnostic_studies Límite: Female / Humans / Male Idioma: En Revista: Clin Exp Allergy Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arachis / Hipersensibilidad al Cacahuete / Dieta / Nueces Tipo de estudio: Clinical_trials / Diagnostic_studies Límite: Female / Humans / Male Idioma: En Revista: Clin Exp Allergy Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Reino Unido