The insulin-like receptor gene expression in the tissues synthesizing gonadotropic hormones at sexual maturation of Drosophila melanogaster females].
Genetika
; 52(11): 1342-4, 2016 Nov.
Article
en En, Ru
| MEDLINE
| ID: mdl-29372799
The insulin/insulin-like growth factor signaling pathway is involved in the regulation of the synthesis of insect gonadotropic hormones, juvenile (JH) and 20-hydroxyecdysone (20E). We carried out the immunohistochemical analysis of the insulin receptor (InR) expression in the corpus allatum (the JH-producing gland) and in the ovarian follicular cells (a site for the synthesis of 20E precursor, ecdysone) in the process of sexual maturation of D. melanogaster females and examined the influence of exogenous JH on the InR expression in these tissues. For the first time, it was demonstrated that InR was expressed in follicular cells and that its expression in corpus allatum and follicular cells of Drosophila females was stage-specific, i.e., the expression intensity in young females greatly exceeded that in mature individuals. We also found a negative feedback loop in the regulation of JH levels by the insulin signaling pathway in Drosophila adults: the experimental increase in the JH titers in young females dramatically reduced the InR expression intensity in corpus allatum and follicular cells.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ovario
/
Maduración Sexual
/
Regulación de la Expresión Génica
/
Proteínas Tirosina Quinasas Receptoras
/
Proteínas de Drosophila
/
Hormonas Juveniles
Límite:
Animals
Idioma:
En
/
Ru
Revista:
Genetika
Año:
2016
Tipo del documento:
Article
Pais de publicación:
Rusia