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Minimizing dose variation from the interplay effect in stereotactic radiation therapy using volumetric modulated arc therapy for lung cancer.
Kubo, Kazuki; Monzen, Hajime; Tamura, Mikoto; Hirata, Makoto; Ishii, Kentaro; Okada, Wataru; Nakahara, Ryuta; Kishimoto, Shun; Kawamorita, Ryu; Nishimura, Yasumasa.
Afiliación
  • Kubo K; Graduate School of Medical Sciences, Department of Medical Physics, Kindai University, Osaka, Japan.
  • Monzen H; Department of Radiation Oncology, Tane General Hospital, Osaka, Japan.
  • Tamura M; Graduate School of Medical Sciences, Department of Medical Physics, Kindai University, Osaka, Japan.
  • Hirata M; Graduate School of Medical Sciences, Department of Medical Physics, Kindai University, Osaka, Japan.
  • Ishii K; Graduate School of Medical Sciences, Department of Medical Physics, Kindai University, Osaka, Japan.
  • Okada W; Department of Radiation Oncology, Tane General Hospital, Osaka, Japan.
  • Nakahara R; Department of Radiation Oncology, Tane General Hospital, Osaka, Japan.
  • Kishimoto S; Department of Radiation Oncology, Tane General Hospital, Osaka, Japan.
  • Kawamorita R; Department of Radiation Oncology, Tane General Hospital, Osaka, Japan.
  • Nishimura Y; Department of Radiation Oncology, Tane General Hospital, Osaka, Japan.
J Appl Clin Med Phys ; 19(2): 121-127, 2018 Mar.
Article en En | MEDLINE | ID: mdl-29368420
It is important to improve the magnitude of dose variation that is caused by the interplay effect. The aim of this study was to investigate the impact of the number of breaths (NBs) to the dose variation for VMAT-SBRT to lung cancer. Data on respiratory motion and multileaf collimator (MLC) sequence were collected from the cases of 30 patients who underwent radiotherapy with VMAT-SBRT for lung cancer. The NBs in the total irradiation time with VMAT and the maximum craniocaudal amplitude of the target were calculated. The MLC sequence complexity was evaluated using the modulation complexity score for VMAT (MCSv). Static and dynamic measurements were performed using a cylindrical respiratory motion phantom and a micro ionization chamber. The 1 standard deviation which were obtained from 10 dynamic measurements for each patient were defined as dose variation caused by the interplay effect. The dose distributions were also verified with radiochromic film to detect undesired hot and cold dose spot. Dose measurements were also performed with different NBs in the same plan for 16 patients in 30 patients. The correlations between dose variations and parameters assessed for each treatment plan including NBs, MCSv, the MCSv/amplitude quotient (TMMCSv), and the MCSv/amplitude quotient × NBs product (IVS) were evaluated. Dose variation was decreased with increasing NBs, and NBs of >40 times maintained the dose variation within 3% in 15 cases. The correlation between dose variation and IVS which were considered NBs was shown stronger (R2  = 0.43, P < 0.05) than TMMCSv (R2  = 0.32, P < 0.05). The NBs is an important factor to reduce the dose variation. The patient who breathes >40 times during irradiation of two partial arcs VMAT (i.e., NBs = 16 breaths per minute) may be suitable for VMAT-SBRT for lung cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Algoritmos / Planificación de la Radioterapia Asistida por Computador / Radiocirugia / Radioterapia de Intensidad Modulada / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Appl Clin Med Phys Asunto de la revista: BIOFISICA Año: 2018 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Algoritmos / Planificación de la Radioterapia Asistida por Computador / Radiocirugia / Radioterapia de Intensidad Modulada / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Appl Clin Med Phys Asunto de la revista: BIOFISICA Año: 2018 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos