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Influence of Interleukin-6 (174G/C) Gene Polymorphism on Obesity in Egyptian Children.
Ibrahim, Ola M; Gabre, Azza A; Sallam, Sara F; El-Alameey, Inas R; Sabry, Rania N; Galal, Essam M; Tawfik, Sawsan M; Zarouk, Waheba A; Mosaad, Rehab M; Ramadan, Abeer.
Afiliación
  • Ibrahim OM; Child Health Department, Medical Division, National Research Centre, Egypt.
  • Gabre AA; Child Health Department, Medical Division, National Research Centre, Egypt.
  • Sallam SF; Child Health Department, Medical Division, National Research Centre, Egypt.
  • El-Alameey IR; Child Health Department, Medical Division, National Research Centre, Egypt.
  • Sabry RN; Child Health Department, Medical Division, National Research Centre, Egypt.
  • Galal EM; Child Health Department, Medical Division, National Research Centre, Egypt.
  • Tawfik SM; Child Health Department, Medical Division, National Research Centre, Egypt.
  • Zarouk WA; Molecular Genetics & Enzymology Department , Human Genetics and Genome Research Division, National Research Centre, Egypt.
  • Mosaad RM; Molecular Genetics & Enzymology Department , Human Genetics and Genome Research Division, National Research Centre, Egypt.
  • Ramadan A; Molecular Genetics & Enzymology Department , Human Genetics and Genome Research Division, National Research Centre, Egypt.
Open Access Maced J Med Sci ; 5(7): 831-835, 2017 Dec 15.
Article en En | MEDLINE | ID: mdl-29362605
BACKGROUND: Obesity is a multi-factorial chronic disorder. A considerable number of studies have been performed to figure out whether there is an association between obesity and polymorphisms of gene IL-6 (174G/C), but the results are equivocal. AIM: This study aimed to find out whether the IL-6 (174G/C) gene was associated with the risk of developing obesity in Egyptian children. SUBJECTS AND METHODS: The study included 149 children and adolescents with age ranged between 9.5 - 18 years. Eighty-five of them were obese which BMIZ-score is > 2, and sixty-four children with BMIZ-score ≤ 2 served as control group. Serum level of IL-6 and genetic analysis for IL-6 (174G/C) gene polymorphism were done. RESULTS: Obese children had significantly higher serum levels of IL-6 as compared to those of control children (P = 0.003). A high percentage of IL-6 polymorphism GC was found in obese subjects (93.7%), while the control group had a higher percentage of IL-6 polymorphism GG (70.6 %). CONCLUSION: Our study showed that carriers of the C allele for the IL-6 (174G/C) polymorphism have higher BMI. As the G174C polymorphism is likely to affect IL-6 expression and its physiological regulation; consequently this polymorphism may affect adiposity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Open Access Maced J Med Sci Año: 2017 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Macedonia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Open Access Maced J Med Sci Año: 2017 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Macedonia