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Methylparaben induces malformations and alterations on apoptosis, oxidant-antioxidant status, ccnd1 and myca expressions in zebrafish embryos.
Ates, Perihan Seda; Ünal, Ismail; Üstündag, Ünsal Veli; Alturfan, Ahmet Ata; Yigitbasi, Türkan; Emekli-Alturfan, Ebru.
Afiliación
  • Ates PS; Department of Biochemistry, Faculty of Dentistry, Marmara University, Maltepe, Istanbul, Turkey.
  • Ünal I; Department of Biochemistry, Faculty of Dentistry, Marmara University, Maltepe, Istanbul, Turkey.
  • Üstündag ÜV; Department of Biochemistry, Faculty of Medicine, Medipol University, Kavacik, Istanbul, Turkey.
  • Alturfan AA; Department of Biochemistry, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
  • Yigitbasi T; Department of Biochemistry, Faculty of Medicine, Medipol University, Kavacik, Istanbul, Turkey.
  • Emekli-Alturfan E; Department of Biochemistry, Faculty of Dentistry, Marmara University, Maltepe, Istanbul, Turkey.
J Biochem Mol Toxicol ; 32(3): e22036, 2018 Mar.
Article en En | MEDLINE | ID: mdl-29360218
Methylparabens (MP) are widely used as preservatives in cosmetics, pharmacy, and food industry. Although acute toxicity studies in animals indicated that parabens are not significantly toxic, the effects of chronic exposure under sublethal doses are still unknown and the number of related studies is limited. Our aim was to evaluate the effects of MP on the development of zebrafish embryos focusing on development, locomotor activity, oxidant-antioxidant status, apoptosis, and ccnd1 and myca expressions. The expressions of ccnd1 and myca were determined by RT-PCR. Lipid peroxidation (LPO), nitric oxide (NO), and glutathione-S-transferase (GST) activities were determined spectrophotometrically. Apoptosis was determined using acridine orange staining. Locomotor activity was measured using touch-evoked movement test. MP exposure increased malformations, LPO, apoptosis, ccnd1 and myca expressions, and decreased GST activities and NO levels compared with the control group. Our findings will lead to further understanding of the mechanism of MP toxicity, and merit further research.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Parabenos / Anomalías Múltiples / Pez Cebra / Regulación de la Expresión Génica / Proteínas Proto-Oncogénicas c-myc / Apoptosis / Ciclina D1 / Proteínas de Pez Cebra Límite: Animals Idioma: En Revista: J Biochem Mol Toxicol Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA / TOXICOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Parabenos / Anomalías Múltiples / Pez Cebra / Regulación de la Expresión Génica / Proteínas Proto-Oncogénicas c-myc / Apoptosis / Ciclina D1 / Proteínas de Pez Cebra Límite: Animals Idioma: En Revista: J Biochem Mol Toxicol Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA / TOXICOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Estados Unidos