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The high molecular weight dipeptidyl peptidase IV Pol d 3 is a major allergen of Polistes dominula venom.
Schiener, Maximilian; Hilger, Christiane; Eberlein, Bernadette; Pascal, Mariona; Kuehn, Annette; Revets, Dominique; Planchon, Sébastien; Pietsch, Gunilla; Serrano, Pilar; Moreno-Aguilar, Carmen; de la Roca, Federico; Biedermann, Tilo; Darsow, Ulf; Schmidt-Weber, Carsten B; Ollert, Markus; Blank, Simon.
Afiliación
  • Schiener M; Center of Allergy and Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, Member of the German Center of Lung Research (DZL), Munich, Germany.
  • Hilger C; Department of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg.
  • Eberlein B; Department of Dermatology and Allergy Biederstein, Technical University of Munich, Munich, Germany.
  • Pascal M; Immunology Department, CDB Hospital Clinic de Barcelona, Universitat de Barcelona, Barcelona, Spain.
  • Kuehn A; Department of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg.
  • Revets D; Department of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg.
  • Planchon S; Department of Environmental Research and Innovation, Luxembourg Institute of Science and Technology, Belvaux, Luxembourg.
  • Pietsch G; Department of Dermatology and Allergy Biederstein, Technical University of Munich, Munich, Germany.
  • Serrano P; Maimonides Institute for Research in Biomedicine (IMIBIC), Córdoba, Spain.
  • Moreno-Aguilar C; Hospital Universitario Reina Sofía, Córdoba, Spain.
  • de la Roca F; Maimonides Institute for Research in Biomedicine (IMIBIC), Córdoba, Spain.
  • Biedermann T; Hospital Universitario Reina Sofía, Córdoba, Spain.
  • Darsow U; Allergy Unit, Pneumology Department, ICR, Hospital Clinic de Barcelona, Barcelona, Spain.
  • Schmidt-Weber CB; Department of Dermatology and Allergy Biederstein, Technical University of Munich, Munich, Germany.
  • Ollert M; Department of Dermatology and Allergy Biederstein, Technical University of Munich, Munich, Germany.
  • Blank S; Center of Allergy and Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, Member of the German Center of Lung Research (DZL), Munich, Germany.
Sci Rep ; 8(1): 1318, 2018 01 22.
Article en En | MEDLINE | ID: mdl-29358620
Hymenoptera venom allergy can cause severe anaphylaxis in untreated patients. Polistes dominula is an important elicitor of venom allergy in Southern Europe as well as in the United States. Due to its increased spreading to more moderate climate zones, Polistes venom allergy is likely to gain importance also in these areas. So far, only few allergens of Polistes dominula venom were identified as basis for component-resolved diagnostics. Therefore, this study aimed to broaden the available panel of important Polistes venom allergens. The 100 kDa allergen Pol d 3 was identified by mass spectrometry and found to be a dipeptidyl peptidase IV. Recombinantly produced Pol d 3 exhibited sIgE-reactivity with approximately 66% of Polistes venom-sensitized patients. Moreover, its clinical relevance was supported by the potent activation of basophils from allergic patients. Cross-reactivity with the dipeptidyl peptidases IV from honeybee and yellow jacket venom suggests the presence of exclusive as well as conserved IgE epitopes. The obtained data suggest a pivotal role of Pol d 3 as sensitizing component of Polistes venom, thus supporting its status as a major allergen of clinical relevance. Therefore, Pol d 3 might become a key element for proper diagnosis of Polistes venom allergy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Venenos de Avispas / Alérgenos / Dipeptidil Peptidasa 4 / Proteínas de Insectos Límite: Humans Idioma: En Revista: Sci Rep Año: 2018 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Venenos de Avispas / Alérgenos / Dipeptidil Peptidasa 4 / Proteínas de Insectos Límite: Humans Idioma: En Revista: Sci Rep Año: 2018 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido