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Calcium carbonate end-capped, folate-mediated Fe3O4@mSiO2 core-shell nanocarriers as targeted controlled-release drug delivery system.
Liu, Min-Chao; Liu, Bing; Chen, Xian-Li; Lin, Hui-Chao; Sun, Xiang-Yu; Lu, Jia-Zheng; Li, Yan-Yu; Yan, Si-Qi; Zhang, Lu-Yong; Zhao, Ping.
Afiliación
  • Liu MC; 1 School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou, China.
  • Liu B; 2 School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China.
  • Chen XL; 3 Medical College of Shaoguan University, Guangdong, China.
  • Lin HC; 1 School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou, China.
  • Sun XY; 1 School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou, China.
  • Lu JZ; 2 School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China.
  • Li YY; 1 School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou, China.
  • Yan SQ; 1 School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou, China.
  • Zhang LY; 2 School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China.
  • Zhao P; 1 School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou, China.
J Biomater Appl ; 32(8): 1090-1104, 2018 03.
Article en En | MEDLINE | ID: mdl-29357775
Magnetic mesoporous silica nanospheres (MMSN) were prepared and the surface was modified with cancer cell-specific ligand folic acid. Calcium carbonate was then employed as acid-activated gatekeepers to cap the mesopores of the MMSN, namely, MMSN-FA-CaCO3. The formation of the MMSN-FA-CaCO3 was proved by several characterization techniques, viz. transmission electron microscopy, zeta potential measurement, Fourier transform infrared spectroscopy, BET surface area measurement, and UV-Vis spectroscopy. Daunomycin was successfully loaded in the MMSN-FA-CaCO3 and the system exhibited sensitive pH stimuli-responsive release characteristics under blood or tumor microenvironment. Cellular uptake by folate receptor (FR)-overexpressing HeLa cells of the MMSN-FA-CaCO3 was higher than that by non-folated-conjugated ones. Intracellular-uptake studies revealed preferential uptake of these nanoparticles into FR-positive [FR(+)] HeLa than FR-negative [FR(-)]A549 cell lines. DAPI stain experiment showed high apoptotic rate of MMSN-FA-DNM-CaCO3 to HeLa cells. The present data suggest that the CaCO3 coating and folic acid modification of MMSN are able to create a targeted, pH-sensitive template for drug delivery system with application in cancer therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carbonato de Calcio / Daunorrubicina / Dióxido de Silicio / Preparaciones de Acción Retardada / Nanopartículas de Magnetita / Ácido Fólico / Antibióticos Antineoplásicos Límite: Humans Idioma: En Revista: J Biomater Appl Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carbonato de Calcio / Daunorrubicina / Dióxido de Silicio / Preparaciones de Acción Retardada / Nanopartículas de Magnetita / Ácido Fólico / Antibióticos Antineoplásicos Límite: Humans Idioma: En Revista: J Biomater Appl Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido