Reproducibility and replicability of rodent phenotyping in preclinical studies.
Neurosci Biobehav Rev
; 87: 218-232, 2018 04.
Article
en En
| MEDLINE
| ID: mdl-29357292
The scientific community is increasingly concerned with the proportion of published "discoveries" that are not replicated in subsequent studies. The field of rodent behavioral phenotyping was one of the first to raise this concern, and to relate it to other methodological issues: the complex interaction between genotype and environment; the definitions of behavioral constructs; and the use of laboratory mice and rats as model species for investigating human health and disease mechanisms. In January 2015, researchers from various disciplines gathered at Tel Aviv University to discuss these issues. The general consensus was that the issue is prevalent and of concern, and should be addressed at the statistical, methodological and policy levels, but is not so severe as to call into question the validity and the usefulness of model organisms as a whole. Well-organized community efforts, coupled with improved data and metadata sharing, have a key role in identifying specific problems and promoting effective solutions. Replicability is closely related to validity, may affect generalizability and translation of findings, and has important ethical implications.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Investigación
/
Conducta Animal
/
Experimentación Animal
Tipo de estudio:
Prognostic_studies
Aspecto:
Ethics
Límite:
Animals
Idioma:
En
Revista:
Neurosci Biobehav Rev
Año:
2018
Tipo del documento:
Article
Pais de publicación:
Estados Unidos