Changes in the 32P incorporation in rat mammary tumor after chronic administration of LH-RH analogs.
Med Oncol Tumor Pharmacother
; 2(4): 243-7, 1985.
Article
en En
| MEDLINE
| ID: mdl-2935686
We studied endogenous phosphorylation in rat transplantable MT/W9A hormone-dependent mammary tumors of untreated rats and of animals treated with LH-RH analogs, the agonist D-Trp-6-LH-RH and the antagonist N-Ac-D-p-Cl-Phe1,2,D-Trp3,D-Arg6,D-Ala10-LH-RH. Incorporation of 32P from 32P-ATP was reduced significantly in tumors of rats treated with agonistic and antagonistic analogs of LH-RH or ovariectomized. The inhibition of protein phosphorylation may be related to tumor regression.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hormona Liberadora de Gonadotropina
/
Neoplasias Mamarias Experimentales
/
Proteínas de Neoplasias
Límite:
Animals
Idioma:
En
Revista:
Med Oncol Tumor Pharmacother
Año:
1985
Tipo del documento:
Article
Pais de publicación:
Reino Unido