Understanding the roles of glutamine synthetase, glutaminase, and glutamate decarboxylase autoantibodies in imbalanced excitatory/inhibitory neurotransmission as etiological mechanisms of autism.

Hamed, Najat O; Al-Ayadhi, Laila; Osman, Mohamed A; Elkhawad, Abdalla O; Qasem, Hanan; Al-Marshoud, Majida; Merghani, Nada M; El-Ansary, Afaf

Hamed, Najat O; Al-Ayadhi, Laila; Osman, Mohamed A; Elkhawad, Abdalla O; Qasem, Hanan; Al-Marshoud, Majida; Merghani, Nada M; El-Ansary, Afaf.

Afiliación

Hamed NO; Department of Medical Biochemistry, University of Medical Sciences and Technology, Khartoum, Sudan.
Al-Ayadhi L; Department of Pharmacology, Almaarefa Colleges for Science & Technology (MCST), Riyadh, Saudi Arabia.
Osman MA; Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia.
Elkhawad AO; Autism Research and Treatment Center, King Khalid University Hospital, Riyadh, Saudi Arabia.
Qasem H; Shaik AL-Amodi Autism Research Chair, King Saud University, Riyadh, Saudi Arabia.
Al-Marshoud M; Department of Medical Biochemistry, University of Medical Sciences and Technology, Khartoum, Sudan.
Merghani NM; Department of Pharmacology, Faculty of Pharmacy, University of Medical Sciences and Technology, Sudan Medical and Scientific Research Institute, Khartoum, Sudan.
El-Ansary A; Kirkwood College, Iowa, USA.

Psychiatry Clin Neurosci ; 72(5): 362-373, 2018 May.

Article en En | MEDLINE | ID: mdl-29356297

Asunto(s)

Trastorno del Espectro Autista/sangre; Autoanticuerpos/sangre; Glutamato Descarboxilasa/inmunología; Glutamato-Amoníaco Ligasa/inmunología; Ácido Glutámico/metabolismo; Glutaminasa/inmunología; Transmisión Sináptica; Ácido gamma-Aminobutírico/metabolismo; Niño; Humanos; Masculino

Palabras clave

autism; excitation; glutamic acid decarboxylase autoantibodies; glutaminase kidney isoform; glutamine synthetase

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoanticuerpos / Transmisión Sináptica / Ácido Glutámico / Trastorno del Espectro Autista / Ácido gamma-Aminobutírico / Glutamato Descarboxilasa / Glutaminasa / Glutamato-Amoníaco Ligasa Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Child / Humans / Male Idioma: En Revista: Psychiatry Clin Neurosci Asunto de la revista: NEUROLOGIA / PSIQUIATRIA Año: 2018 Tipo del documento: Article País de afiliación: Sudán Pais de publicación: Australia

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