Dual inhibition of HY023016 based on binding properties of platelet membrane receptor subunit glycoprotein Ib&#945; and thrombin exosites.

Chen, Qiu-Fang; Cui, Shuang; Shen, Hui-Liang; Chen, Xiang; Li, Yun-Zhan; Wu, Qian; Xu, Yun-Gen; Gong, Guo-Qing

Dual inhibition of HY023016 based on binding properties of platelet membrane receptor subunit glycoprotein Ibα and thrombin exosites.

Chen, Qiu-Fang; Cui, Shuang; Shen, Hui-Liang; Chen, Xiang; Li, Yun-Zhan; Wu, Qian; Xu, Yun-Gen; Gong, Guo-Qing.

Afiliación

Chen QF; China Pharmaceutical University, Department of Pharmacology, Nanjing 211198, China.
Cui S; China Pharmaceutical University, Department of Pharmacology, Nanjing 211198, China.
Shen HL; China Pharmaceutical University, Department of Pharmacology, Nanjing 211198, China.
Chen X; China Pharmaceutical University, Department of Pharmacology, Nanjing 211198, China.
Li YZ; China Pharmaceutical University, Department of Pharmacology, Nanjing 211198, China.
Wu Q; China Pharmaceutical University, Department of Pharmacology, Nanjing 211198, China.
Xu YG; China Pharmaceutical University, Department of Medicinal Chemistry, Nanjing 211198, China. Electronic address: xu_yungen@hotmail.com.
Gong GQ; China Pharmaceutical University, Department of Pharmacology, Nanjing 211198, China. Electronic address: gonggq@hotmail.com.

Eur J Pharmacol ; 822: 51-58, 2018 Mar 05.

Article en En | MEDLINE | ID: mdl-29355554

Asunto(s)

Dabigatrán/farmacología; Fibrinolíticos/farmacología; Complejo GPIb-IX de Glicoproteína Plaquetaria/metabolismo; Trombina/química; Trombina/metabolismo; Sitios de Unión; Humanos; Complejo GPIb-IX de Glicoproteína Plaquetaria/química; Glicoproteínas de Membrana Plaquetaria/metabolismo; Unión Proteica/efectos de los fármacos; Dominios Proteicos

Palabras clave

Exosite; Glycoprotein Ibα; HY023016; Thrombin; von Willebrand factor

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trombina / Complejo GPIb-IX de Glicoproteína Plaquetaria / Fibrinolíticos / Dabigatrán Límite: Humans Idioma: En Revista: Eur J Pharmacol Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos

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