Your browser doesn't support javascript.
loading
Rapid Turnover of Cortical NCAM1 Regulates Synaptic Reorganization after Peripheral Nerve Injury.
Ko, Hyoung-Gon; Choi, Jun-Hyeok; Park, Dong Ik; Kang, SukJae Joshua; Lim, Chae-Seok; Sim, Su-Eon; Shim, Jaehoon; Kim, Ji-Il; Kim, Siyong; Choi, Tae-Hyeok; Ye, Sanghyun; Lee, Jaehyun; Park, Pojeong; Kim, Somi; Do, Jeehaeh; Park, Jihye; Islam, Md Ariful; Kim, Hyun Jeong; Turck, Christoph W; Collingridge, Graham L; Zhuo, Min; Kaang, Bong-Kiun.
Afiliación
  • Ko HG; School of Biological Sciences, Seoul National University, 1 Gwanangno, Gwanak-gu, Seoul 08826, South Korea; Center for Neuron and Disease, Frontier Institutes of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
  • Choi JH; School of Biological Sciences, Seoul National University, 1 Gwanangno, Gwanak-gu, Seoul 08826, South Korea.
  • Park DI; Max Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, Kraepelinstr. 2, 80804 Munich, Germany.
  • Kang SJ; School of Biological Sciences, Seoul National University, 1 Gwanangno, Gwanak-gu, Seoul 08826, South Korea.
  • Lim CS; School of Biological Sciences, Seoul National University, 1 Gwanangno, Gwanak-gu, Seoul 08826, South Korea.
  • Sim SE; School of Biological Sciences, Seoul National University, 1 Gwanangno, Gwanak-gu, Seoul 08826, South Korea.
  • Shim J; School of Biological Sciences, Seoul National University, 1 Gwanangno, Gwanak-gu, Seoul 08826, South Korea.
  • Kim JI; School of Biological Sciences, Seoul National University, 1 Gwanangno, Gwanak-gu, Seoul 08826, South Korea.
  • Kim S; School of Biological Sciences, Seoul National University, 1 Gwanangno, Gwanak-gu, Seoul 08826, South Korea.
  • Choi TH; School of Biological Sciences, Seoul National University, 1 Gwanangno, Gwanak-gu, Seoul 08826, South Korea.
  • Ye S; School of Biological Sciences, Seoul National University, 1 Gwanangno, Gwanak-gu, Seoul 08826, South Korea.
  • Lee J; School of Biological Sciences, Seoul National University, 1 Gwanangno, Gwanak-gu, Seoul 08826, South Korea.
  • Park P; School of Biological Sciences, Seoul National University, 1 Gwanangno, Gwanak-gu, Seoul 08826, South Korea.
  • Kim S; School of Biological Sciences, Seoul National University, 1 Gwanangno, Gwanak-gu, Seoul 08826, South Korea.
  • Do J; School of Biological Sciences, Seoul National University, 1 Gwanangno, Gwanak-gu, Seoul 08826, South Korea.
  • Park J; School of Biological Sciences, Seoul National University, 1 Gwanangno, Gwanak-gu, Seoul 08826, South Korea.
  • Islam MA; School of Biological Sciences, Seoul National University, 1 Gwanangno, Gwanak-gu, Seoul 08826, South Korea.
  • Kim HJ; Department of Dental Anesthesiology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul 03080, South Korea.
  • Turck CW; Max Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, Kraepelinstr. 2, 80804 Munich, Germany.
  • Collingridge GL; Centre for Synaptic Plasticity, School of Physiology, Pharmacology & Neuroscience, University of Bristol, Bristol BS8 1TD, UK; Department of Physiology, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada; Center for Neuron and Disease, Frontier Insti
  • Zhuo M; Department of Physiology, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada; Center for Neuron and Disease, Frontier Institutes of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China. Electronic address: min.zhuo@utoronto.ca.
  • Kaang BK; School of Biological Sciences, Seoul National University, 1 Gwanangno, Gwanak-gu, Seoul 08826, South Korea; Center for Neuron and Disease, Frontier Institutes of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China. Electronic address: kaang@snu.ac.kr.
Cell Rep ; 22(3): 748-759, 2018 01 16.
Article en En | MEDLINE | ID: mdl-29346771
Peripheral nerve injury can induce pathological conditions that lead to persistent sensitized nociception. Although there is evidence that plastic changes in the cortex contribute to this process, the underlying molecular mechanisms are unclear. Here, we find that activation of the anterior cingulate cortex (ACC) induced by peripheral nerve injury increases the turnover of specific synaptic proteins in a persistent manner. We demonstrate that neural cell adhesion molecule 1 (NCAM1) is one of the molecules involved and show that it mediates spine reorganization and contributes to the behavioral sensitization. We show striking parallels in the underlying mechanism with the maintenance of NMDA-receptor- and protein-synthesis-dependent long-term potentiation (LTP) in the ACC. Our results, therefore, demonstrate a synaptic mechanism for cortical reorganization and suggest potential avenues for neuropathic pain treatment.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sinapsis / Transmisión Sináptica / Antígeno CD56 / Traumatismos de los Nervios Periféricos / Giro del Cíngulo Límite: Animals Idioma: En Revista: Cell Rep Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sinapsis / Transmisión Sináptica / Antígeno CD56 / Traumatismos de los Nervios Periféricos / Giro del Cíngulo Límite: Animals Idioma: En Revista: Cell Rep Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos