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The effects of booster vaccination of hepatitis B vaccine on children 5-15 years after primary immunization: A 5-year follow-up study.
Wu, Zikang; Yao, Jun; Bao, Hongdan; Chen, Yongdi; Lu, Shunshun; Li, Jing; Yang, Linna; Jiang, Zhenggang; Ren, Jingjing; Xu, Kai-Jin; Ruan, Bing; Yang, Shi-Gui; Xie, Tian-Sheng; Li, Qian.
Afiliación
  • Wu Z; a School of Medicine , Ningbo University , Ningbo , Zhejiang , China.
  • Yao J; b The National Science and Technology Project , Zhejiang Provincial Center for Disease Control and Prevention , Hangzhou , Zhejiang , China.
  • Bao H; a School of Medicine , Ningbo University , Ningbo , Zhejiang , China.
  • Chen Y; b The National Science and Technology Project , Zhejiang Provincial Center for Disease Control and Prevention , Hangzhou , Zhejiang , China.
  • Lu S; c Ningbo Medical Center Lihuili Eastern Hospital , Ningbo , Zhejiang , China.
  • Li J; d Zhejiang Provincial Hospital , Hangzhou , Zhejiang , China.
  • Yang L; d Zhejiang Provincial Hospital , Hangzhou , Zhejiang , China.
  • Jiang Z; b The National Science and Technology Project , Zhejiang Provincial Center for Disease Control and Prevention , Hangzhou , Zhejiang , China.
  • Ren J; e State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Key Laboratory of Infectious Diseases, the First Affiliated Hospital , School of Medicine, Zhejiang University , Hangzhou , Zhejiang , China.
  • Xu KJ; e State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Key Laboratory of Infectious Diseases, the First Affiliated Hospital , School of Medicine, Zhejiang University , Hangzhou , Zhejiang , China.
  • Ruan B; e State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Key Laboratory of Infectious Diseases, the First Affiliated Hospital , School of Medicine, Zhejiang University , Hangzhou , Zhejiang , China.
  • Yang SG; e State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Key Laboratory of Infectious Diseases, the First Affiliated Hospital , School of Medicine, Zhejiang University , Hangzhou , Zhejiang , China.
  • Xie TS; e State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Key Laboratory of Infectious Diseases, the First Affiliated Hospital , School of Medicine, Zhejiang University , Hangzhou , Zhejiang , China.
  • Li Q; b The National Science and Technology Project , Zhejiang Provincial Center for Disease Control and Prevention , Hangzhou , Zhejiang , China.
Hum Vaccin Immunother ; 14(5): 1251-1256, 2018 05 04.
Article en En | MEDLINE | ID: mdl-29337651
The aim of this study was to evaluate changes in hepatitis B surface antibody titers (anti-HBs) after booster vaccinations in children aged 5-15 y and to provide suitable immunization strategies. A total of 2208 children were initially enrolled in screening, and 559 children were finally included. The participants were divided into 2 groups according to their pre-booster anti-HBs levels: Group I, <10 mIU/ml and Group II, ≥10 mIU/ml. Group I was administered 3 doses of booster hepatitis B vaccine (0-1-6 months, 10 µg), and Group II was administered 1 dose of booster hepatitis B vaccine (10 µg). The antibody titer changes were examined at 4 time points: 1 month after dose 1 and dose 3, and 1 year and 5 years after dose 3. The protective seroconversion rates at those points were 95.65%, 99.67%, 97.59% and 91.05% (p < 0.001), respectively, in Group I, and 100.00%, 99.87%, 99.66% and 98.21% (χ2 = 6.04, p = 0.11), respectively, in Group II. The GMT in subjects aged 5-9 y were higher than that in subjects aged 10-15 y in both Group I and Group II at 1 month after dose 1, but no difference was observed at the other three time points. This study demonstrates that booster vaccination has a good medium-term effect. A booster dose for subjects with protective antibodies is not necessary but effective, and 3 doses of hepatitis B vaccination are recommended for those who have lost immunological memory. Receiving booster immunization at the age of 10-15 years may be more appropriate for individuals living in HBV high epidemic areas.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunización Secundaria / Vacunación / Vacunas contra Hepatitis B / Hepatitis B / Anticuerpos contra la Hepatitis B Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Hum Vaccin Immunother Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunización Secundaria / Vacunación / Vacunas contra Hepatitis B / Hepatitis B / Anticuerpos contra la Hepatitis B Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Hum Vaccin Immunother Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos