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Chronic hepatitis C virus infection and subsequent HIV viral load among women with HIV initiating antiretroviral therapy.
Willis, Sarah J; Cole, Stephen R; Westreich, Daniel; Edmonds, Andrew; Hurt, Christopher B; Albrecht, Svenja; Anastos, Kathryn; Augenbraun, Michael; Fischl, Margaret; French, Audrey L; Kalapila, Aley G; Karim, Roksana; Peters, Marion G; Plankey, Michael; Seaberg, Eric C; Tien, Phyllis C; Adimora, Adaora A.
Afiliación
  • Willis SJ; Department of Epidemiology, Gillings School of Global Public Health.
  • Cole SR; Department of Epidemiology, Gillings School of Global Public Health.
  • Westreich D; Department of Epidemiology, Gillings School of Global Public Health.
  • Edmonds A; Department of Epidemiology, Gillings School of Global Public Health.
  • Hurt CB; Institute for Global Health & Infectious Diseases, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
  • Albrecht S; Division of Infectious Diseases, University of Mississippi Medical Center, Jackson, Mississippi.
  • Anastos K; Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx.
  • Augenbraun M; Department of Medicine, SUNY Downstate Medical Center, Brooklyn, New York.
  • Fischl M; Miller School of Medicine, University of Miami, Miami, Florida.
  • French AL; Division of Infectious Diseases, Stroger Hospital of Cook County, Chicago, Illinois.
  • Kalapila AG; Division of Infectious Diseases, School of Medicine, Emory University, Atlanta, Georgia.
  • Karim R; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles.
  • Peters MG; Department of Medicine, University of California, San Francisco, San Francisco, California.
  • Plankey M; Department of Medicine, Division of Infectious Diseases, Georgetown University Medical Center, Washington, DC.
  • Seaberg EC; Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
  • Tien PC; Department of Medicine, University of California, San Francisco, San Francisco, California.
  • Adimora AA; Department of Epidemiology, Gillings School of Global Public Health.
AIDS ; 32(5): 653-661, 2018 03 13.
Article en En | MEDLINE | ID: mdl-29334550
OBJECTIVES: One in four persons living with HIV is coinfected with hepatitis C virus (HCV). Biological and behavioral mechanisms may increase HIV viral load among coinfected persons. Therefore, we estimated the longitudinal effect of chronic HCV on HIV suppression after ART initiation among women with HIV (WWH). DESIGN: HIV RNA was measured every 6 months among 441 WWH in the Women's Interagency HIV Study who initiated ART from 2000 to 2015. METHODS: Log-binomial regression models were used to compare the proportion of study visits with detectable HIV RNA between women with and without chronic HCV. Robust sandwich variance estimators accounted for within-person correlation induced by repeated HIV RNA measurements during follow-up. We controlled for confounding and selection bias (because of loss to follow-up and death) using inverse probability-of-exposure-and-censoring weights. RESULTS: One hundred and fourteen women (25%) had chronic HCV before ART initiation. Overall, the proportion of visits with detectable HIV RNA was similar among women with and without chronic HCV [relative risk (RR) 1.19 (95% CI 0.72, 1.95)]. Six months after ART initiation, the proportion of visits with detectable HIV RNA among women with chronic HCV was 1.88 (95% CI 1.41-2.51) times that among women without HCV, at 2 years, the ratio was 1.60 (95% CI 1.17-2.19), and by 6 years there was no difference (1.03; 95% CI 0.60-1.79). CONCLUSION: Chronic HCV may negatively impact early HIV viral response to ART. These findings reaffirm the need to test persons with HIV for HCV infection, and increase engagement in HIV care and access to HCV treatment among persons with HIV/HCV coinfection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / VIH / Carga Viral / Hepatitis C Crónica / Antirretrovirales Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: AIDS Asunto de la revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / VIH / Carga Viral / Hepatitis C Crónica / Antirretrovirales Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: AIDS Asunto de la revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido