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The urgent need for a harmonized severity scoring system for acute allergic reactions.
Muraro, A; Fernandez-Rivas, M; Beyer, K; Cardona, V; Clark, A; Eller, E; Hourihane, J O B; Jutel, M; Sheikh, A; Agache, I; Allen, K J; Angier, E; Ballmer-Weber, B; Bilò, M B; Bindslev-Jensen, C; Camargo, C A; Cianferoni, A; DunnGalvin, A; Eigenmann, P A; Halken, S; Hoffmann-Sommergruber, K; Lau, S; Nilsson, C; Poulsen, L K; Rueff, F; Spergel, J; Sturm, G; Timmermans, F; Torres, M J; Turner, P; van Ree, R; Wickman, M; Worm, M; Mills, E N C; Roberts, G.
Afiliación
  • Muraro A; Food Allergy Referral Centre Veneto Region, Department of Women and Child Health, Padua General University Hospital, Padua, Italy.
  • Fernandez-Rivas M; Allergy Department, Hospital Clinico San Carlos, Madrid, Spain.
  • Beyer K; Department of Pediatric Pneumology and Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany.
  • Cardona V; Allergy Section, Department of Internal Medicine, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
  • Clark A; Allergy Section, Department of Medicine, University of Cambridge, Cambridge, UK.
  • Eller E; Odense Research Center for Anaphylaxis, Department Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark.
  • Hourihane JOB; Paediatrics and Child Health, University College Cork, Cork, Ireland.
  • Jutel M; Wroclaw Medical University, Wroclaw, Poland.
  • Sheikh A; Asthma UK Centre for Applied Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, UK.
  • Agache I; Faculty of Medicine, Department of Allergy and Clinical Immunology, Transylvania University Brasov, Brasov, Romania.
  • Allen KJ; Murdoch Children's Research Institute, Department of Allergy, Royal Children's Hospital, Melbourne, Vic, Australia.
  • Angier E; Department of Paediatrics, University of Melbourne, Melbourne, Vic, Australia.
  • Ballmer-Weber B; University of Manchester, Manchester, UK.
  • Bilò MB; Department of Immunology and Allergy, Northern General Hospital, Sheffield, UK.
  • Bindslev-Jensen C; Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich, Switzerland.
  • Camargo CA; Allergy Unit, Department of Internal Medicine, University Hospital of Ancona, Ancona, Italy.
  • Cianferoni A; Odense Research Center for Anaphylaxis, Department Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark.
  • DunnGalvin A; Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Eigenmann PA; Allergy And Immunology Division, Department of Pediatrics, Perelman School of Medicine, The Children's Hospital of Philadelphia, The University of Pennsylvania, Philadelphia, PA, USA.
  • Halken S; Paediatrics and Child Health, University College Cork, Cork, Ireland.
  • Hoffmann-Sommergruber K; Pediatric Allergy Unit, Department of Pediatrics, University Hospitals of Geneva, Geneva, Switzerland.
  • Lau S; Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.
  • Nilsson C; Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.
  • Poulsen LK; Department of Pediatric Pneumology and Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany.
  • Rueff F; Department of Clinical Science and Education, Karolinska Institutet and Sachs' Children's Hospital, Stockholm, Sweden.
  • Spergel J; Allergy Clinic, Copenhagen University Hospital, Copenhagen, Denmark.
  • Sturm G; Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität, Munich, Germany.
  • Timmermans F; The Children's Hospital of Philadelphia, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA.
  • Torres MJ; Department of Dermatology and Venerology, Medical University of Graz and Outpatient Allergy Clinic Reumannplatz, Vienna, Austria.
  • Turner P; Netherlands Anaphylaxis Network, Dordrecht, The Netherlands.
  • van Ree R; Allergy Unit, IBIMA, Regional University Hospital of Malaga, UMA, Málaga, Spain.
  • Wickman M; Section of Paediatrics (Allergy and Infectious Diseases) and MRC, Asthma UK Centre in Allergic Mechanisms of Asthma, Imperial College London, London, UK.
  • Worm M; Department of Experimental Immunology and Otorhinolaryngology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
  • Mills ENC; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden.
  • Roberts G; Sachs' Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden.
Allergy ; 73(9): 1792-1800, 2018 09.
Article en En | MEDLINE | ID: mdl-29331045
The accurate assessment and communication of the severity of acute allergic reactions are important to patients, clinicians, researchers, the food industry, and public health and regulatory authorities. Severity has different meanings to different stakeholders with patients and clinicians rating the significance of particular symptoms very differently. Many severity scoring systems have been generated, most focusing on the severity of reactions following exposure to a limited group of allergens. They are heterogeneous in format, none has used an accepted developmental approach, and none has been validated. Their wide range of outcome formats has led to difficulties with interpretation and application. Therefore, there is a persisting need for an appropriately developed and validated severity scoring system for allergic reactions that work across the range of allergenic triggers and address the needs of different stakeholder groups. We propose a novel approach to develop and then validate a harmonized scoring system for acute allergic reactions, based on a data-driven method that is informed by clinical and patient experience and other stakeholders' perspectives. We envisage two formats: (i) a numerical score giving a continuum from mild to severe reactions that are clinically meaningful and are useful for allergy healthcare professionals and researchers, and (ii) a three-grade-based ordinal format that is simple enough to be used and understood by other professionals and patients. Testing of reliability and validity of the new approach in a range of settings and populations will allow eventual implementation of a standardized scoring system in clinical studies and routine practice.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipersensibilidad / Anafilaxia Tipo de estudio: Guideline Límite: Humans Idioma: En Revista: Allergy Año: 2018 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Dinamarca
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipersensibilidad / Anafilaxia Tipo de estudio: Guideline Límite: Humans Idioma: En Revista: Allergy Año: 2018 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Dinamarca