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Differential effects of phototherapy, adalimumab and betamethasone-calcipotriol on effector and regulatory T cells in psoriasis.
Kotb, I S; Lewis, B J; Barker, R N; Ormerod, A D.
Afiliación
  • Kotb IS; Immunity, Infection and Inflammation Programme, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, U.K.
  • Lewis BJ; Department of Dermatology, Andrology and STDs, Mansoura University, Mansoura, Egypt.
  • Barker RN; Immunity, Infection and Inflammation Programme, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, U.K.
  • Ormerod AD; Immunity, Infection and Inflammation Programme, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, U.K.
Br J Dermatol ; 179(1): 127-135, 2018 07.
Article en En | MEDLINE | ID: mdl-29330859
BACKGROUND: Psoriasis is a chronic T-cell-mediated skin disease with marked social and economic burdens. Current treatments are unsatisfactory, with unpredictable remission times and incompletely understood modes of action. Recent advances in our understanding of the pathogenesis of psoriasis have identified the imbalance between CD4+ T effector cells, particularly the T helper (Th)17 subset, and regulatory T cells (Tregs) as key to the development of psoriatic lesions, and therefore a novel therapeutic target. OBJECTIVES: To quantify in patients the effects of three commonly used psoriasis treatment modalities on the Th1, Th2, Th17 and Treg subsets, and to test whether any change correlates with clinical response. METHODS: Flow cytometry was used to enumerate Th1, Th2, Th17 and Treg subsets in blood and skin of patients with psoriasis before and after receiving any of the following treatments: narrowband ultraviolet B (NB-UVB), adalimumab and topical betamethasone-calcipotriol combination (Dovobet® ) RESULTS: All patients responded clinically to the treatments. NB-UVB significantly increased the numbers of circulating and skin Tregs, while, by contrast, adalimumab reduced Th17 cells in these compartments, and Dovobet had dual effects by both increasing Tregs and reducing Th17 cells. CONCLUSIONS: The differential effects reported here for the above-mentioned treatment modalities could be exploited to optimize or design therapeutic strategies to overcome the inflammatory drivers more effectively and restore the Th17-Treg balance in psoriasis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psoriasis / Terapia Ultravioleta / Calcitriol / Betametasona / Linfocitos T Reguladores / Fármacos Dermatológicos / Adalimumab Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Br J Dermatol Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psoriasis / Terapia Ultravioleta / Calcitriol / Betametasona / Linfocitos T Reguladores / Fármacos Dermatológicos / Adalimumab Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Br J Dermatol Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido