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IgA nephropathy and IgA vasculitis with nephritis have a shared feature involving galactose-deficient IgA1-oriented pathogenesis.
Suzuki, Hitoshi; Yasutake, Junichi; Makita, Yuko; Tanbo, Yuki; Yamasaki, Kohei; Sofue, Tadashi; Kano, Toshiki; Suzuki, Yusuke.
Afiliación
  • Suzuki H; Department of Nephrology, Juntendo University Faculty of Medicine, Tokyo, Japan.
  • Yasutake J; Department of Nephrology, Juntendo University Faculty of Medicine, Tokyo, Japan; Nephrology Research Labs, Kyowa Hakko Kirin Co., Ltd., Tokyo, Japan.
  • Makita Y; Department of Nephrology, Juntendo University Faculty of Medicine, Tokyo, Japan.
  • Tanbo Y; Department of Nephrology, Juntendo University Faculty of Medicine, Tokyo, Japan; Nephrology Research Labs, Kyowa Hakko Kirin Co., Ltd., Tokyo, Japan.
  • Yamasaki K; Department of Nephrology, Juntendo University Faculty of Medicine, Tokyo, Japan; Nephrology Research Labs, Kyowa Hakko Kirin Co., Ltd., Tokyo, Japan.
  • Sofue T; Division of Nephrology and Dialysis, Department of CardioRenal and Cerebrovascular Medicine, Faculty of Medicine, Kagawa University, Takamatsu, Japan.
  • Kano T; Department of Nephrology, Juntendo University Faculty of Medicine, Tokyo, Japan.
  • Suzuki Y; Department of Nephrology, Juntendo University Faculty of Medicine, Tokyo, Japan. Electronic address: yusuke@juntendo.ac.jp.
Kidney Int ; 93(3): 700-705, 2018 03.
Article en En | MEDLINE | ID: mdl-29329643
Galactose-deficient IgA1 has been proposed as an important effector molecule in IgA nephropathy (IgAN). We previously showed that the galactose-deficient IgA1-specific monoclonal antibody KM55 can detect circulating galactose-deficient IgA1 in patients with IgAN, enabling us to study the molecular roles of galactose-deficient IgA1. Herein, we further examined the pathophysiological significance of galactose-deficient IgA1 in glomerular deposits of patients with IgAN by immunohistochemistry using KM55. Immunostaining of galactose-deficient IgA1 with KM55 was performed in paraffin-embedded sections of renal biopsy specimens from 48 patients with IgAN and 49 patients with other renal diseases such as lupus nephritis, HCV-related nephropathy, IgA vasculitis with nephritis (IgA-VN), and membranous nephropathy. Glomerular galactose-deficient IgA1 was specifically detected in IgAN and IgA-VN but not in the other renal diseases. Galactose-deficient IgA1 was localized predominantly in the mesangial region as IgA deposition. However, galactose-deficient IgA1 was not detected in patients with lupus nephritis accompanied by glomerular IgA deposition. Thus, our study strongly suggests that IgAN and IgA-VN have a shared feature regarding galactose-deficient IgA1-oriented pathogenesis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasculitis / Inmunoglobulina A / Galactosa / Glomerulonefritis por IGA / Glomérulos Renales Tipo de estudio: Diagnostic_studies / Etiology_studies Límite: Humans Idioma: En Revista: Kidney Int Año: 2018 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasculitis / Inmunoglobulina A / Galactosa / Glomerulonefritis por IGA / Glomérulos Renales Tipo de estudio: Diagnostic_studies / Etiology_studies Límite: Humans Idioma: En Revista: Kidney Int Año: 2018 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos