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Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity.
Mitroulis, Ioannis; Ruppova, Klara; Wang, Baomei; Chen, Lan-Sun; Grzybek, Michal; Grinenko, Tatyana; Eugster, Anne; Troullinaki, Maria; Palladini, Alessandra; Kourtzelis, Ioannis; Chatzigeorgiou, Antonios; Schlitzer, Andreas; Beyer, Marc; Joosten, Leo A B; Isermann, Berend; Lesche, Mathias; Petzold, Andreas; Simons, Kai; Henry, Ian; Dahl, Andreas; Schultze, Joachim L; Wielockx, Ben; Zamboni, Nicola; Mirtschink, Peter; Coskun, Ünal; Hajishengallis, George; Netea, Mihai G; Chavakis, Triantafyllos.
Afiliación
  • Mitroulis I; Institute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, Dresden, Germany. Electronic address: ioannis.mitroulis@uniklinikum-dresden.de.
  • Ruppova K; Institute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, Dresden, Germany.
  • Wang B; Department of Microbiology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA.
  • Chen LS; Institute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, Dresden, Germany.
  • Grzybek M; Paul Langerhans Institute Dresden, Helmholtz Zentrum München, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.
  • Grinenko T; Institute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, Dresden, Germany.
  • Eugster A; DFG-Center for Regenerative Therapies Dresden, Dresden, Germany.
  • Troullinaki M; Institute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, Dresden, Germany.
  • Palladini A; Institute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, Dresden, Germany; Paul Langerhans Institute Dresden, Helmholtz Zentrum München, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; German Center for
  • Kourtzelis I; Institute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, Dresden, Germany.
  • Chatzigeorgiou A; Institute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, Dresden, Germany.
  • Schlitzer A; Myeloid Cell Biology, LIMES-Institute, University of Bonn, Bonn, Germany.
  • Beyer M; Department of Genomics and Immunoregulation, Life and Medical Science Institute, University of Bonn, Bonn, Germany; Molecular Immunology in Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
  • Joosten LAB; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6525 GA, Nijmegen, the Netherlands.
  • Isermann B; Institute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University, Magdeburg, Germany.
  • Lesche M; Deep Sequencing Group, Biotechnology Center, Technische Universität Dresden, Dresden, Germany.
  • Petzold A; Deep Sequencing Group, Biotechnology Center, Technische Universität Dresden, Dresden, Germany.
  • Simons K; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany; Lipotype GmbH, Dresden, Germany.
  • Henry I; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
  • Dahl A; Deep Sequencing Group, Biotechnology Center, Technische Universität Dresden, Dresden, Germany.
  • Schultze JL; Department of Genomics and Immunoregulation, Life and Medical Science Institute, University of Bonn, Bonn, Germany; PRECISE - Platform for Single Cell Genomics and Epigenomics at the German Center for Neurodegenerative Diseases and the University of Bonn, Bonn, Germany.
  • Wielockx B; Institute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, Dresden, Germany.
  • Zamboni N; Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.
  • Mirtschink P; Institute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, Dresden, Germany.
  • Coskun Ü; Paul Langerhans Institute Dresden, Helmholtz Zentrum München, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.
  • Hajishengallis G; Department of Microbiology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA.
  • Netea MG; Department of Genomics and Immunoregulation, Life and Medical Science Institute, University of Bonn, Bonn, Germany; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6525 GA, Nijmegen, the Netherlands.
  • Chavakis T; Institute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, Dresden, Germany. Electronic address: triantafyllos.chavakis@uniklinikum-dresden.de.
Cell ; 172(1-2): 147-161.e12, 2018 01 11.
Article en En | MEDLINE | ID: mdl-29328910
Trained innate immunity fosters a sustained favorable response of myeloid cells to a secondary challenge, despite their short lifespan in circulation. We thus hypothesized that trained immunity acts via modulation of hematopoietic stem and progenitor cells (HSPCs). Administration of ß-glucan (prototypical trained-immunity-inducing agonist) to mice induced expansion of progenitors of the myeloid lineage, which was associated with elevated signaling by innate immune mediators, such as IL-1ß and granulocyte-macrophage colony-stimulating factor (GM-CSF), and with adaptations in glucose metabolism and cholesterol biosynthesis. The trained-immunity-related increase in myelopoiesis resulted in a beneficial response to secondary LPS challenge and protection from chemotherapy-induced myelosuppression in mice. Therefore, modulation of myeloid progenitors in the bone marrow is an integral component of trained immunity, which to date, was considered to involve functional changes of mature myeloid cells in the periphery.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Progenitoras Mieloides / Inmunidad Innata / Memoria Inmunológica Límite: Animals Idioma: En Revista: Cell Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Progenitoras Mieloides / Inmunidad Innata / Memoria Inmunológica Límite: Animals Idioma: En Revista: Cell Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos