Your browser doesn't support javascript.
loading
Novel 1,4-naphthoquinone derivatives induce apoptosis via ROS-mediated p38/MAPK, Akt and STAT3 signaling in human hepatoma Hep3B cells.
Liu, Chang; Shen, Gui-Nan; Luo, Ying-Hua; Piao, Xian-Ji; Jiang, Xue-Yuan; Meng, Ling-Qi; Wang, Yue; Zhang, Yi; Wang, Jia-Ru; Wang, Hao; Xu, Wan-Ting; Li, Jin-Qian; Liu, Yang; Wu, Yi-Qin; Sun, Hu-Nan; Han, Ying-Hao; Jin, Mei-Hua; Cui, Yu-Dong; Fang, Nan-Zhu; Jin, Cheng-Hao.
Afiliación
  • Liu C; Department of Biochemistry and Molecular Biology, College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Xinyang Road 2, 163319, Daqing, China.
  • Shen GN; Department of Biochemistry and Molecular Biology, College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Xinyang Road 2, 163319, Daqing, China.
  • Luo YH; Department of Animal Science, College of Animal Science & Veterinary Medicine, Heilongjiang Bayi Agricultural University, Xinyang Road 2, 163319, Daqing, China.
  • Piao XJ; Department of Gynaecology and Obstetrics, The Fifth Affiliated Hospital of Harbin Medical University, Jianshe Road 213, 163316, Daqing, China.
  • Jiang XY; Department of Biochemistry and Molecular Biology, College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Xinyang Road 2, 163319, Daqing, China.
  • Meng LQ; Department of Biochemistry and Molecular Biology, College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Xinyang Road 2, 163319, Daqing, China.
  • Wang Y; Department of Biochemistry and Molecular Biology, College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Xinyang Road 2, 163319, Daqing, China.
  • Zhang Y; Department of Biochemistry and Molecular Biology, College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Xinyang Road 2, 163319, Daqing, China.
  • Wang JR; Department of Biochemistry and Molecular Biology, College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Xinyang Road 2, 163319, Daqing, China.
  • Wang H; Department of Biochemistry and Molecular Biology, College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Xinyang Road 2, 163319, Daqing, China.
  • Xu WT; Department of Biochemistry and Molecular Biology, College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Xinyang Road 2, 163319, Daqing, China.
  • Li JQ; Department of Biochemistry and Molecular Biology, College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Xinyang Road 2, 163319, Daqing, China.
  • Liu Y; Department of Biochemistry and Molecular Biology, College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Xinyang Road 2, 163319, Daqing, China.
  • Wu YQ; Department of Biochemistry and Molecular Biology, College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Xinyang Road 2, 163319, Daqing, China.
  • Sun HN; Department of Biochemistry and Molecular Biology, College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Xinyang Road 2, 163319, Daqing, China.
  • Han YH; Department of Biochemistry and Molecular Biology, College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Xinyang Road 2, 163319, Daqing, China.
  • Jin MH; Department of Biochemistry and Molecular Biology, College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Xinyang Road 2, 163319, Daqing, China.
  • Cui YD; Department of Biochemistry and Molecular Biology, College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Xinyang Road 2, 163319, Daqing, China.
  • Fang NZ; Department of Animal Science, College of Agriculture, Yanbian University, Gongyuan Street 997, 133002, Yanji, China. Electronic address: nzfang@ybu.edu.cn.
  • Jin CH; Department of Biochemistry and Molecular Biology, College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Xinyang Road 2, 163319, Daqing, China. Electronic address: jinchenghao3727@qq.com.
Int J Biochem Cell Biol ; 96: 9-19, 2018 03.
Article en En | MEDLINE | ID: mdl-29326072
1,4-Naphthoquinone and its derivatives have shown some efficacy as therapeutic compounds for cancer and inflammation, though their clinical application is limited by their side-effects. To reduce the toxicity of these compounds and optimize their effects, we synthesized two 1,4-naphthoquinone derivatives-2-butylsulfinyl- 1,4-naphthoquinone (BSNQ) and 2-octylsulfinyl-1,4-naphthoquinone (OSNQ)-and investigated their effects and underlying mechanisms in hepatocellular carcinoma cells. BSNQ and OSNQ decreased cell viability and significantly induced apoptosis, accompanied by the accumulation of reactive oxygen species (ROS). However, pretreatment with N-acetyl-l-cysteine, a specific ROS scavenger, blocked apoptosis. Western blot results indicated that BSNQ and OSNQ up-regulated the phosphorylation of p38 and JNK, and down-regulated the phosphorylation of ERK, Akt and STAT3, and that these effects were blocked by N-acetyl-l-cysteine. Furthermore, BSNQ and OSNQ suppressed tumor growth and modulated MAPK and STAT3 signaling in mouse xenografts without detectable effects on body weight or hematological parameters. These results indicate that BSNQ and OSNQ induce apoptosis in human hepatoma Hep3B cells via ROS-mediated p38/MAPK, Akt and STAT3 signaling pathways, suggesting that these 1,4-naphthoquinone derivatives may provide promising new anticancer agents to treat HCC.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Naftoquinonas / Especies Reactivas de Oxígeno / Apoptosis / Carcinoma Hepatocelular / Sistema de Señalización de MAP Quinasas / Proteínas Quinasas p38 Activadas por Mitógenos / Proteínas Proto-Oncogénicas c-akt / Factor de Transcripción STAT3 / Neoplasias Hepáticas Límite: Humans Idioma: En Revista: Int J Biochem Cell Biol Asunto de la revista: BIOQUIMICA Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Naftoquinonas / Especies Reactivas de Oxígeno / Apoptosis / Carcinoma Hepatocelular / Sistema de Señalización de MAP Quinasas / Proteínas Quinasas p38 Activadas por Mitógenos / Proteínas Proto-Oncogénicas c-akt / Factor de Transcripción STAT3 / Neoplasias Hepáticas Límite: Humans Idioma: En Revista: Int J Biochem Cell Biol Asunto de la revista: BIOQUIMICA Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos