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Persistent mammalian orthoreovirus, coxsackievirus and adenovirus co-infection in a child with a primary immunodeficiency detected by metagenomic sequencing: a case report.
Lewandowska, Dagmara W; Capaul, Riccarda; Prader, Seraina; Zagordi, Osvaldo; Geissberger, Fabienne-Desirée; Kügler, Martin; Knorr, Marcus; Berger, Christoph; Güngör, Tayfun; Reichenbach, Janine; Shah, Cyril; Böni, Jürg; Zbinden, Andrea; Trkola, Alexandra; Pachlopnik Schmid, Jana; Huber, Michael.
Afiliación
  • Lewandowska DW; Institute of Medical Virology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
  • Capaul R; Institute of Medical Virology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
  • Prader S; Division of Immunology, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland.
  • Zagordi O; Institute of Medical Virology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
  • Geissberger FD; Institute of Medical Virology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
  • Kügler M; Institute of Medical Virology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
  • Knorr M; Present address: Unilabs, Ringstrasse 12, 8600, Dübendorf, Switzerland.
  • Berger C; Institute of Medical Virology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
  • Güngör T; Division of Infectious Diseases and Hospital Epidemiology, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland.
  • Reichenbach J; Division of Stem Cell Transplantation, University Children's Hospital Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.
  • Shah C; Division of Immunology, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland.
  • Böni J; Institute of Medical Virology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
  • Zbinden A; Institute of Medical Virology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
  • Trkola A; Institute of Medical Virology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
  • Pachlopnik Schmid J; Institute of Medical Virology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
  • Huber M; Division of Immunology, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland.
BMC Infect Dis ; 18(1): 33, 2018 01 11.
Article en En | MEDLINE | ID: mdl-29325543
BACKGROUND: We report a rare case of Mammalian orthoreovirus (MRV) infection in a child with a primary immunodeficiency (PID). Infections with Mammalian orthoreovirus are very rare and probably of zoonotic origin. Only a few cases have been described so far, including one with similar pathogenesis as in our case. CASE PRESENTATION: The patient, age 11, presented with flu-like symptoms and persistent severe diarrhea. Enterovirus has been detected over several months, however, exact typing of a positive cell culture remained inconclusive. Unbiased metagenomic sequencing then detected MRV in stool samples from several time points. The sequencing approach further revealed co-infection with a recombinant Coxsackievirus and Adenovirus. MRV-specific antibodies detected by immunofluorescence proved that the patient seroconverted. CONCLUSION: This case highlights the potential of unbiased metagenomic sequencing in supplementing routine diagnostic methods, especially in situations of chronic infection with multiple viruses as seen here in an immunocompromised host. The origin, transmission routes and implications of MRV infection in humans merit further investigation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Adenoviridae / Infecciones por Reoviridae / Infecciones por Coxsackievirus / Metagenómica / Síndromes de Inmunodeficiencia Tipo de estudio: Etiology_studies Límite: Child / Female / Humans Idioma: En Revista: BMC Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2018 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Adenoviridae / Infecciones por Reoviridae / Infecciones por Coxsackievirus / Metagenómica / Síndromes de Inmunodeficiencia Tipo de estudio: Etiology_studies Límite: Child / Female / Humans Idioma: En Revista: BMC Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2018 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido