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Prevalence and determinants of vitamin D deficiency in the third trimester of pregnancy: a multicentre study in Switzerland.
Krieger, Jean-Philippe; Cabaset, Sophie; Canonica, Claudia; Christoffel, Ladina; Richard, Aline; Schröder, Therese; von Wattenwyl, Begoña Lipp; Rohrmann, Sabine; Lötscher, Katharina Quack.
Afiliación
  • Krieger JP; 1Division of Chronic Disease Epidemiology,Epidemiology, Biostatistics and Prevention Institute,University of Zurich,Hirschengraben 82,8001 Zurich,Switzerland.
  • Cabaset S; 1Division of Chronic Disease Epidemiology,Epidemiology, Biostatistics and Prevention Institute,University of Zurich,Hirschengraben 82,8001 Zurich,Switzerland.
  • Canonica C; 2Gynecology and Obstetrics,Regional Hospital of Bellinzona,Carrale Morinascio 7A,6500 Bellinzona,Switzerland.
  • Christoffel L; 3Gynecology Unit,Oberengadin Hospital,Via Nuova 3,7503 Samedan,Switzerland.
  • Richard A; 1Division of Chronic Disease Epidemiology,Epidemiology, Biostatistics and Prevention Institute,University of Zurich,Hirschengraben 82,8001 Zurich,Switzerland.
  • Schröder T; 3Gynecology Unit,Oberengadin Hospital,Via Nuova 3,7503 Samedan,Switzerland.
  • von Wattenwyl BL; 2Gynecology and Obstetrics,Regional Hospital of Bellinzona,Carrale Morinascio 7A,6500 Bellinzona,Switzerland.
  • Rohrmann S; 1Division of Chronic Disease Epidemiology,Epidemiology, Biostatistics and Prevention Institute,University of Zurich,Hirschengraben 82,8001 Zurich,Switzerland.
  • Lötscher KQ; 4Clinic of Obstetrics,University Hospital Zurich,Frauenklinikstrasse 10,8006 Zurich,Switzerland.
Br J Nutr ; 119(3): 299-309, 2018 02.
Article en En | MEDLINE | ID: mdl-29318983
Vitamin D deficiency during pregnancy is associated with negative health consequences for mothers and their infants. Data on the vitamin D status of pregnant women in Switzerland are scarce. A three-centre study was conducted in the obstetric departments of Zurich, Bellinzona and Samedan (Switzerland) to investigate the prevalence and determinants of vitamin D deficiency (serum 25-hydroxyvitamin D (25(OH)D)<50 nmol/l) in 3rd-trimester pregnant women living in Switzerland (n 305), and the correlation between 25(OH)D in pregnant women and their offspring at birth (n 278). Demographic and questionnaire data were used to explore the determinants of vitamin D deficiency. Median concentration of serum 25(OH)D in the third trimester of pregnancy was 46·0 nmol/l (1st-3rd quartiles: 30·5-68·5), representing a 53·4 % prevalence of vitamin D deficiency. 25(OH)D levels in the umbilcal cord blood (median: 50·0 nmol/l; 1st-3rd quartiles: 31·0-76·6) strongly correlated with mothers' serum 25(OH)D (Spearman's correlation ρ=0·79, P<0·001). Multivariable logistic regression analysis showed that significant determinants of vitamin D deficiency in pregnant women were centre of study, country of origin, season of delivery and vitamin D supplement intake. Near-term BMI, skin colour, use of sunscreen and mothers' education, although each not individually significant, collectively improved the ability of the model to explain vitamin D status. Low vitamin D levels were common in this sample of pregnant women and their newborns' cord blood. Vitamin D supplement intake was the most actionable determinant of vitamin D status, suggesting that vitamin D supplementation during pregnancy should receive more attention in clinical practice.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones del Embarazo / Deficiencia de Vitamina D Tipo de estudio: Clinical_trials / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Pregnancy País/Región como asunto: Europa Idioma: En Revista: Br J Nutr Año: 2018 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones del Embarazo / Deficiencia de Vitamina D Tipo de estudio: Clinical_trials / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Pregnancy País/Región como asunto: Europa Idioma: En Revista: Br J Nutr Año: 2018 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido