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Spearmint Extract Improves Working Memory in Men and Women with Age-Associated Memory Impairment.
Herrlinger, Kelli A; Nieman, Kristin M; Sanoshy, Kristen D; Fonseca, Brenda A; Lasrado, Joanne A; Schild, Arianne L; Maki, Kevin C; Wesnes, Keith A; Ceddia, Michael A.
Afiliación
  • Herrlinger KA; 1 Kemin Foods, LC , Des Moines, IA.
  • Nieman KM; 2 Biofortis Research Services/Mérieux NutriSciences , Addison, IL.
  • Sanoshy KD; 2 Biofortis Research Services/Mérieux NutriSciences , Addison, IL.
  • Fonseca BA; 1 Kemin Foods, LC , Des Moines, IA.
  • Lasrado JA; 1 Kemin Foods, LC , Des Moines, IA.
  • Schild AL; 2 Biofortis Research Services/Mérieux NutriSciences , Addison, IL.
  • Maki KC; 2 Biofortis Research Services/Mérieux NutriSciences , Addison, IL.
  • Wesnes KA; 3 Bracket, LLC , Wayne, PA.
  • Ceddia MA; 4 Department of Psychology, Northumbria University , Newcastle, United Kingdom .
J Altern Complement Med ; 24(1): 37-47, 2018 Jan.
Article en En | MEDLINE | ID: mdl-29314866
OBJECTIVE: The purpose of this study was to investigate the effects of supplementation with a spearmint (Mentha spicata L.) extract, high in polyphenols including rosmarinic acid, on cognitive performance, sleep, and mood in individuals with age-associated memory impairment (AAMI). DESIGN: Subjects with AAMI (N = 90; 67% female; age = 59.4 ± 0.6 years) were randomly assigned (n = 30/group) to consume 900, 600, or 0 mg/day (two capsules, once daily) spearmint extract for 90 days, in this double-blind, placebo-controlled trial. Assessments were completed for cognition (days 0, 45, and 90), sleep (days 0 and 90), and mood (days 0 and 90) by using the Cognitive Drug Research (CDR) System™, Leeds Sleep Evaluation Questionnaire (LSEQ), and Profile of Mood States (POMS™), respectively. RESULTS: Quality of working memory and spatial working memory accuracy improved after supplementation with 900 mg/day spearmint extract by 15% (p = 0.0469) and 9% (p = 0.0456), respectively, versus placebo. Subjects consuming 900 mg/day spearmint extract reported improvement in their ability to fall asleep, relative to subjects consuming placebo (p = 0.0046). Overall treatment effects were evident for vigor-activity (p = 0.0399), total mood disturbance (p = 0.0374), and alertness and behavior following wakefulness (p = 0.0415), with trends observed for improvements after spearmint supplementation relative to placebo. CONCLUSIONS: These results suggest that the distinct spearmint extract may be a beneficial nutritional intervention for cognitive health in older subjects with AAMI.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Trastornos de la Memoria / Memoria a Corto Plazo Tipo de estudio: Clinical_trials / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: J Altern Complement Med Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Trastornos de la Memoria / Memoria a Corto Plazo Tipo de estudio: Clinical_trials / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: J Altern Complement Med Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos