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Photoactivation of Ligands for Extrinsically and Intrinsically Triggered Disassembly of Amphiphilic Nanoassemblies.
Gao, Jingjing; Liu, Xiaochi; Secinti, Hatice; Jiang, Ziwen; Munkhbat, Oyuntuya; Xu, Yisheng; Guo, Xuhong; Thayumanavan, S.
Afiliación
  • Gao J; Department of Chemistry, University of Massachusetts Amherst, Amherst, MA, 01003, USA.
  • Liu X; Department of Chemistry, University of Massachusetts Amherst, Amherst, MA, 01003, USA.
  • Secinti H; State-Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China.
  • Jiang Z; Department of Chemistry, University of Massachusetts Amherst, Amherst, MA, 01003, USA.
  • Munkhbat O; Department of Chemistry, University of Massachusetts Amherst, Amherst, MA, 01003, USA.
  • Xu Y; Department of Chemistry, University of Massachusetts Amherst, Amherst, MA, 01003, USA.
  • Guo X; State-Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China.
  • Thayumanavan S; State-Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China.
Chemistry ; 24(8): 1789-1794, 2018 Feb 06.
Article en En | MEDLINE | ID: mdl-29314349
Specific response to the concurrent presence of two different inputs is one of the hallmarks of incorporating specificities in nature. Artificial nanoassemblies that concurrently respond to two very different inputs are of great interest in a variety of applications, especially in biomedicine. Here, we present a design strategy for amphiphilic nanoassemblies with such capabilities, enabled by photocaging a ligand moiety that is capable of binding to a specific protein. New molecular designs that offer nanoassemblies that respond to either of two inputs or only to the concurrent presence of two inputs are outlined. Such biomimetic nanoassemblies could find use in many applications, including drug delivery and diagnostics.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania