Identification of specific feed-forward apoptosis mechanisms and associated higher survival rates for low grade glioma and lung squamous cell carcinoma.

Sikaria, Dhiraj; Tu, Yaping N; Fisler, Diana A; Mauro, James A; Blanck, George

Sikaria, Dhiraj; Tu, Yaping N; Fisler, Diana A; Mauro, James A; Blanck, George.

Afiliación

Sikaria D; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, USA.
Tu YN; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, USA.
Fisler DA; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, USA.
Mauro JA; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, USA.
Blanck G; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, USA. gblanck@health.usf.edu.

J Cancer Res Clin Oncol ; 144(3): 459-468, 2018 Mar.

Article en En | MEDLINE | ID: mdl-29305708

RESUMEN

The mechanisms of cell proliferation due to the overexpression of certain transcription factors (TFs) have been well documented in the cancer setting. However, many of these same TFs have pro-apoptotic effects, particularly when expressed or activated at high levels, a process referred to as feed-forward apoptosis (FFA). To determine whether cancers could be stratified on the basis of specific FFA signatures, RNASeq data representing samples from the cancer genome atlas were analyzed, revealing that high expression of the pro-proliferative TFs, MYC and YY1, is associated with a favorable outcome in low-grade glioma (LGG) and lung squamous cell carcinoma (LUSC), respectively. Analysis of the RNASeq data also led to the identification of specific apoptosis-effector genes whose expression levels correlate with increased survival rates, for both LGG and LUSC. Although FFA has been demonstrated as a general effect in cancer, in this report, for the first time, results identify specific TFs and their responsive effector genes that distinguish subsets of cancer samples undergoing more or less of a FFA process in a way that is associated with distinct patient survival rates.

Asunto(s)

Apoptosis/fisiología; Carcinoma de Células Escamosas/mortalidad; Carcinoma de Células Escamosas/patología; Glioma/mortalidad; Glioma/patología; Neoplasias Pulmonares/mortalidad; Neoplasias Pulmonares/patología; Apoptosis/genética; Proteínas Reguladoras de la Apoptosis/genética; Carcinoma de Células Escamosas/genética; Perfilación de la Expresión Génica; Regulación Neoplásica de la Expresión Génica; Glioma/genética; Secuenciación de Nucleótidos de Alto Rendimiento; Humanos; Neoplasias Pulmonares/genética; Clasificación del Tumor; Transducción de Señal/genética; Tasa de Supervivencia; Factores de Transcripción/metabolismo

Palabras clave

Apoptosis-effector genes; Feed-forward apoptosis; Glioma; Lung cancer; Pro-proliferative transcription factors; The cancer genome atlas

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / Apoptosis / Glioma / Neoplasias Pulmonares Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Cancer Res Clin Oncol Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania

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