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E-beam sterilizable thermoplastics elastomers for healthcare devices: Mechanical, morphology, and in vivo studies.
Balaji, Ananad Bellam; Ratnam, Chantara Thevy; Khalid, Mohammad; Walvekar, Rashmi.
Afiliación
  • Balaji AB; 1 Faculty of Engineering, Department of Chemical and Environmental Engineering, 69861 University of Nottingham Malaysia Campus , Semenyih, Selangor, Malaysia.
  • Ratnam CT; 2 Radiation Processing Technology Division, Malaysian Nuclear Agency, Bangi, Selangor, Malaysia.
  • Khalid M; 3 School of Science & Technology, Research Centre for Nano-materials & Energy Technology, 65189 Sunway University , Subang Jaya, Selangor, Malaysia.
  • Walvekar R; 4 Energy Research Division, 65214 Taylor's University , Lakeside Campus, Subang Jaya, Selangor, Malaysia.
J Biomater Appl ; 32(8): 1049-1062, 2018 03.
Article en En | MEDLINE | ID: mdl-29298552
The effect of electron beam radiation on ethylene-propylene diene terpolymer/polypropylene blends is studied as an attempt to develop radiation sterilizable polypropylene/ethylene-propylene diene terpolymer blends suitable for medical devices. The polypropylene/ethylene-propylene diene terpolymer blends with mixing ratios of 80/20, 50/50, 20/80 were prepared in an internal mixer at 165°C and a rotor speed of 50 rpm/min followed by compression molding. The blends and the individual components were radiated using 3.0 MeV electron beam accelerator at doses ranging from 0 to 100 kGy in air and room temperature. All the samples were tested for tensile strength, elongation at break, hardness, impact strength, and morphological properties. After exposing to 25 and 100 kGy radiation doses, 50% PP blend was selected for in vivo studies. Results revealed that radiation-induced crosslinking is dominating in EPDM dominant blends, while radiation-induced degradation is prevailing in PP dominant blends. The 20% PP blend was found to be most compatible for 20-60 kGy radiation sterilization. The retention in impact strength with enhanced tensile strength of 20% PP blend at 20-60 kGy believed to be associated with increased compatibility between PP and EPDM along with the radiation-induced crosslinking. The scanning electron micrographs of the fracture surfaces of the PP/EPDM blends showed evidences consistent with the above contentation. The in vivo studies provide an instinct that the radiated blends are safe to be used for healthcare devices.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polipropilenos / Materiales Biocompatibles / Elastómeros / Etilenos Límite: Animals Idioma: En Revista: J Biomater Appl Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2018 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polipropilenos / Materiales Biocompatibles / Elastómeros / Etilenos Límite: Animals Idioma: En Revista: J Biomater Appl Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2018 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Reino Unido